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Anti-Calcium Channel (α_1A Subunit) (P/Q-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

Name: Anti-Calcium Channel (α<SUB>1A</SUB> Subunit) (P/Q-type of Voltage-gated Ca<SUP>2+</SUP> Channel) antibody produced in rabbit
Brand: SIGMA
Price: 379 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

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Size/SKU	Availability	Price
0.05 mL	Check Cart for Availability	$379.00
0.2 mL	Check Cart for Availability	$1,200.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02095950

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, WB

Citations:

$379.00

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

antigen (major) 190 kDa, antigen (minor) 210 kDa

species reactivity

rat, mouse

technique(s)

immunohistochemistry: 1:100, western blot: 1:200

UniProt accession no.

P54282

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cacna1a(12286)
rat ... Cacna1a(25398)

Description

Immunogen

synthetic peptide corresponding to amino acids 865-881 of the α_1A subunit of rat brain voltage-gated calcium channel (VGCC, CNA1) (with additional N-terminal lysine and tyrosine) conjugated to KLH.

Application

Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 and western blotting at a dilution of 1:200.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)

Biochem/physiol Actions

The Ca_v2.1 P/Q voltage-dependent calcium channel is encoded by the CACNA1A gene in humans. It is a pore-forming essential subunit embedded in the plasma membrane. Mutation in this gene causes a number of human neurologic diseases including familial hemiplegic migraine. CACNA1A is associated with both hemiplegic migraine and migraine with aura in patients. Mutation in this gene is the cause of Type 2 episodic ataxia (EA2) the most common subtype among a group of rare hereditary syndromes characterized by recurrent attacks of ataxia.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	C5488	C1478	C1603
Sigma-Aldrich C1353 Anti-Calcium Channel (α_1A Subunit) (P/Q-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	$Anti-Calcium Channel (α1G Subunit) (T-type Voltage-Gated Ca2+ Channel) antibody produced in rabbit ~1 mg/mL, fractionated antiserum, buffered aqueous solution$ Sigma-Aldrich C5488 Anti-Calcium Channel (α_1G Subunit) (T-type Voltage-Gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich C1478 Anti-Calcium Channel (α_1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich C1603 Anti-Calcium Channel (α_1C Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit
description affinity isolated antibody, lyophilized powder	description ~1 mg/mL, fractionated antiserum, buffered aqueous solution	description affinity isolated antibody, lyophilized powder	description affinity isolated antibody
antibody form affinity isolated antibody	antibody form fractionated antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
technique(s) immunohistochemistry: 1:100, western blot: 1:200	technique(s) western blot: 5-10 μg/mL	technique(s) immunoprecipitation (IP): suitable, western blot: 1:100-1:200 using rat brain membranes, immunocytochemistry: suitable using rat brain sections	technique(s) immunohistochemistry: suitable using Rat brain sections, western blot: 1:200 using Rat brain and rat heart membranes

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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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