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Anti-Calcium Channel (α_1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

Name: Anti-Calcium Channel (α<SUB>1B</SUB> Subunit) (N-type of Voltage-gated Ca<SUP>2+</SUP> Channel) antibody produced in rabbit
Brand: SIGMA
Price: 1050 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

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0.2 mL	Available to ship TODAYfromMILWAUKEE	$1,050.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02095951

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ICC, IP, WB

Citations:

$1,050.00

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

antigen 210 kDa (low), antigen 240 kDa (high)

species reactivity

rat, mouse

technique(s)

immunocytochemistry: suitable using rat brain sections, immunoprecipitation (IP): suitable, western blot: 1:100-1:200 using rat brain membranes

UniProt accession no.

Q02294

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cacna1b(12287)
rat ... Cacna1b(257648)

Description

General description

The calcium channel, voltage-dependent, N type, α1B subunit (CACNA1B) or Cav2.2 gene consists of 47 exons and 46 introns, spanning 244kb. The gene is mapped to human chromosome 9q34. The encoded protein is a member of the voltage-gated calcium channel family.

Immunogen

synthetic peptide corresponding to amino acids 851-867 of the α_1B subunit of rat brain voltage-gated calcium channel (VGCC, CNB1), with additional N-terminal lysine and tyrosine, conjugated to KLH.¹

Application

Anti-Calcium Channel (α1B Subunit) (N-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:

immunocytochemistry using rat brain sections
immunoprecipitation
western blotting at a dilution of 1:100-1:200 using rat brain membranes

Anti-Calcium Channel (α1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit has been used in immunofluorescence analysis.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)

Biochem/physiol Actions

Calcium channel, voltage-dependent, N type, α1B subunit (CACNA1B) plays a vital role in regulation of trafficking and biophysical properties of voltage-gated calcium channels. Members of voltage-gated calcium channel family act as key transducers of cell surface membrane potential changes to local intracellular calcium transients that initiate various physiological events. The N-type voltage-gated calcium channels (VGCCs) expressed mainly in the neurons, facilitate neurotransmitter release at the sympathetic nerve terminals. CACNA1B is expressed on presynaptic nerve terminals of nociceptors control neurotransmitter release.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	C1728	C5105	C1353
Sigma-Aldrich C1478 Anti-Calcium Channel (α_1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich C1728 Anti-Calcium Channel (α_1D Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich C5105 Anti-Calcium Channel (α₂/δ-1 Subunit) antibody produced in rabbit	Sigma-Aldrich C1353 Anti-Calcium Channel (α_1A Subunit) (P/Q-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit
description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, lyophilized powder
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information mouse ... Cacna1b(12287) rat ... Cacna1b(257648)	Gene Information human ... CACNA1D(776) mouse ... Cacna1d(12289) rat ... Cacna1d(29716)	Gene Information human ... CACNA2D1(781) mouse ... Cacna2d1(12293) rat ... Cacna2d1(25399)	Gene Information mouse ... Cacna1a(12286) rat ... Cacna1a(25398)
mol wt antigen 210 kDa (low), antigen 240 kDa (high)	mol wt -	mol wt -	mol wt antigen (major) 190 kDa, antigen (minor) 210 kDa

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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