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C1603

Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CACH2, Anti-CACN2, Anti-CACNL1A1, Anti-CCHL1A1, Anti-CaV1.2, Anti-LQT8, Anti-TS, Anti-TS. LQT8

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Size/SKUAvailabilityPrice
0.2 mL
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$1,040.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02095952
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
14

$1,040.00

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biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat, mouse, rabbit

technique(s)

immunohistochemistry: suitable using Rat brain sections, western blot: 1:200 using Rat brain and rat heart membranes

UniProt accession no.

Q13936

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cacna1c(12288)

General description

L-type of Voltage-gated Ca2+ Channels (L-type VGCC) is a high voltage-activated channel that exerts spatial and temporal control over cellular calcium concentrations and modulates function such as neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression and neuronal survival. Calcium dependent processes are important in synaptic modification and thus alterations in calcium channel function may be important for both modifying synaptic plasticity and also in age-related neurodegenerative diseases. Calcium channel antagonists are used as antiarrhythmics and in the treatment of hypertension and may even be neuroprotective in Parkinson′s Disease. Calcium Channel α1C subunit is a pore-forming subunit that together with β subunits generates the necessary signal for membrane targeting of class C L-type calcium channels.

Immunogen

synthetic peptide corresponding to amino acids 848 to 865 of rat α1C.

Application

Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit has been used in:
  • SDS-PAGE
  • western blotting
  • coimmunoprecipitation
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Rabbit polyclonal anti-Calcium Channel α1C subunit antibody is used to tag class C L-type calcium channel subunit α1C for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of calcium channel subunit α1C in class C L-type voltage-gated Ca2+ channel subunit complexes.

Biochem/physiol Actions

Anti-Voltage-gated Calcium Channel α1C subunit recognizes the α1C subunit by immunoblotting in rat brain and rat heart membranes. Reactivity has been confirmed for rat, mouse, rabbit and human.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit affinity isolated antibody

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Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit affinity isolated antibody, lyophilized powder

Sigma-Aldrich

C1728

Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

description

affinity isolated antibody

description

affinity isolated antibody, lyophilized powder

description

affinity isolated antibody, lyophilized powder

description

affinity isolated antibody, lyophilized powder

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

technique(s)

immunohistochemistry: suitable using Rat brain sections, western blot: 1:200 using Rat brain and rat heart membranes

technique(s)

immunocytochemistry: suitable, western blot: 1:200 using rat heart membranes

technique(s)

western blot: 1:200 using lysate from the ND7/23 cell line

technique(s)

immunocytochemistry: 1:30-1:150, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1:100-1:200

Gene Information

mouse ... Cacna1c(12288)

Gene Information

human ... CACNA1C(775)
mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)

Gene Information

rat ... Cacna1h(114862)

Gene Information

human ... CACNA1D(776)
mouse ... Cacna1d(12289)
rat ... Cacna1d(29716)

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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