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C221

Carboxy-PTIO potassium salt

synthetic (organic), ≥98% (TLC), NO scavenger, powder

Synonym(s):

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt

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10 mg
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$199.00

About This Item

Empirical Formula (Hill Notation):
C14H16KN2O4
CAS Number:
148819-94-7
Molecular Weight:
315.39
UNSPSC Code:
12352200
PubChem Substance ID:
24892474
NACRES:
NA.32
MDL number:
MFCD00216153

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Product Name

Carboxy-PTIO potassium salt,

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (TLC)

form

powder

mp

>270 °C

solubility

H2O: 100 mg/mL, DMSO: soluble (lit.)(lit.), methanol: soluble (lit.)(lit.)

storage temp.

2-8°C

SMILES string

[K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C

InChI

1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1

InChI key

VYEUQMVIGXFZQU-UHFFFAOYSA-M

General description

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO).

Application

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Biochem/physiol Actions

Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO2). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.
Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase.

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This Item
217386P4154H8759
Carboxy-PTIO potassium salt

Sigma-Aldrich

C221

Carboxy-PTIO potassium salt

Carboxy-PTIO, Sodium Salt Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

Sigma-Aldrich

217386

Carboxy-PTIO, Sodium Salt

Polyinosinic acid potassium salt Homopolymer

Sigma-Aldrich

P4154

Polyinosinic acid potassium salt

4-Hydroxy-3-methoxyphenylglycol sulfate potassium salt ≥98% (HPLC), powder

Sigma-Aldrich

H8759

4-Hydroxy-3-methoxyphenylglycol sulfate potassium salt

assay

≥98% (TLC)

assay

≥97% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

form

powder

form

solid

form

lyophilized powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: 100 mg/mL, methanol: soluble (lit.)(lit.), DMSO: soluble (lit.)(lit.)

solubility

HEPES Buffer: 0.4 mg/mL

solubility

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

solubility

H2O: 50 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000538263
0000538263
MKDB6274
MKDB1944
MKCX2402

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Nitric oxide scavenger carboxy-PTIO potentiates the inhibition of dopamine uptake by nitric oxide donors
Cao B J and Reith M EA
European Journal of Pharmacology, 448(1), 27-30 (2002)
Raymond N Allan et al.
Nitric oxide : biology and chemistry, 65, 43-49 (2017-02-27)
Bacterial biofilms show high tolerance towards antibiotics and are a significant problem in clinical settings where they are a primary cause of chronic infections. Novel therapeutic strategies are needed to improve anti-biofilm efficacy and support reduction in antibiotic use. Treatment
Megumi Hada et al.
International journal of molecular sciences, 20(18) (2019-09-07)
Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple exchanges for human
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Global Trade Item Number

SKUGTIN
C221-10MG04061833475379

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