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C2235

CB 1954

solid

Synonym(s):

5-(1-Aziridinyl)-2,4-dinitrobenzamide, 5-(Aziridin-1-yl)-2,4-dinitrobenzamide

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Pack SizeSKUAvailabilityPrice
50 mg
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$611.00
$519.35

About This Item

CAS Number:
21919-05-1
NACRES:
NA.32
PubChem Substance ID:
24278301
UNSPSC Code:
12352204
MDL number:
MFCD00869490

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assay

≥94% (HPLC)

Quality Level

200

form

solid

storage temp.

−20°C

SMILES string

NC(=O)c1cc(N2CC2)c(cc1[N+]([O-])=O)[N+]([O-])=O

InChI

1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)

InChI key

WOCXQMCIOTUMJV-UHFFFAOYSA-N

Application

CB 1954 has been used in drug-induced ablation studies.

Biochem/physiol Actions

CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase 2.

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This Item
C1997SML0525S5321
CB 1954 solid

Sigma-Aldrich

C2235

CB 1954

CYM-5442 ≥98% (HPLC)

Sigma-Aldrich

C1997

CYM-5442

kb-NB142-70 ≥97% (HPLC)

Sigma-Aldrich

SML0525

kb-NB142-70

S15535 ≥98% (HPLC), solid

Sigma-Aldrich

S5321

S15535

assay

≥94% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

form

solid

form

solid

form

powder

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ6707
SLCB5559
SLCB5348
SLBS3090V
SLBS0463V

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Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Gareth A Prosser et al.
Biochemical pharmacology, 85(8), 1091-1103 (2013-02-13)
Two potentially complementary approaches to improve the anti-cancer strategy gene-directed enzyme prodrug therapy (GDEPT) are discovery of more efficient prodrug-activating enzymes, and development of more effective prodrugs. Here we demonstrate the utility of a flexible screening system based on the
Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage
Corbeaux T, et al.
Proceedings of the National Academy of Sciences of the USA, 1-6 (2010)
Andrew Christofferson et al.
Biochemical Society transactions, 37(Pt 2), 413-418 (2009-03-18)
NTR (nitroreductase NfsB from Escherichia coli) is a flavoprotein with broad substrate specificity, reducing nitroaromatics and quinones using either NADPH or NADH. One of its substrates is the prodrug CB1954 (5-[aziridin-1-yl]-2,4-dinitrobenzamide), which is converted into a cytotoxic agent; so NTR/CB1954
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Global Trade Item Number

SKUGTIN
C2235-50MG04061833475423

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