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C2538

Carboplatin

DNA cross-linking agent, powder

Synonym(s):

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

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Size/SKUAvailabilityPrice
100 mg

Available to ship TODAYfromMILWAUKEE

$254.00
250 mg

Available to ship TODAYfromMILWAUKEE

$513.00

About This Item

Linear Formula:
[C4H6(CO2)2]Pt(NH3)2
CAS Number:
Molecular Weight:
371.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
255-446-0
MDL number:
Form:
powder

$254.00


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Product Name

Carboplatin,

form

powder

Quality Segment

antibiotic activity spectrum

neoplastics

originator

Bristol-Myers Squibb

SMILES string

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-L

General description

Carboplatin is used to treat testicular, ovarian and breast cancer.

Application

Carboplatin has been used:
  • in chemotherapy-induced thrombocytopenia mouse model and treatment
  • to induce cell death in a large subset of colorectal cancer cells
  • in the evaluation of cell proliferation and chemosensitivity
  • as a positive control for suppressed cell growth

Biochem/physiol Actions

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
1096407216100MBP711
description

-

description

United States Pharmacopeia (USP) Reference Standard

description

An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.

description

British Pharmacopoeia (BP) Reference Standard

form

powder

form

-

form

solid

form

solid

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

originator

Bristol-Myers Squibb

originator

-

originator

-

originator

-

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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