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C277

Chloro-IB-MECA

solid, ≥98% (HPLC)

Synonym(s):

2-Chloro-N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, Cl-IB-MECA

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAY

$982.00
25 mg

Available to ship TODAY

$3,850.00

About This Item

Empirical Formula (Hill Notation):
C18H18ClIN6O4
CAS Number:
Molecular Weight:
544.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$982.00


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Quality Segment

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL

SMILES string

CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc23

InChI

1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1

InChI key

IPSYPUKKXMNCNQ-PFHKOEEOSA-N

Biochem/physiol Actions

2-chloro-N(6)-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (Cl-IB-MECA) is a adenosine receptor. It protects against myocardial ischemia/reperfusion injury in mice.

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This Item
119139A236E2387
description

solid, ≥98% (HPLC)

description

A highly selective agonist of adenosine A3 receptor (Ki = 330 pM)

description

solid

description

powder

form

solid

form

solid

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

solubility

DMSO: >20 mg/mL

solubility

DMSO: 20 mg/mL

solubility

ethanol: 1 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL, H2O: insoluble, dilute aqueous base: 3.5 mg/mL, DMSO: 10 mg/mL

solubility

DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.), 0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.), ethanol: soluble (Solutions may be stored for several days at 4 °C.), H2O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.)

color

white

color

white

color

off-white

color

white

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Gene Information

-

Gene Information

human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)


Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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