C4116
Cyclopamine hydrate
≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor
Synonym(s):
11-deoxojervine hydrate
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Available to ship TODAYfromMILWAUKEE | $282.00 |
5 mg | Available to ship TODAYfromMILWAUKEE | $1,240.00 |
About This Item
Product Name
Cyclopamine hydrate, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: soluble ≥5 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1
InChI
1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1
InChI key
KDAGJRDPNXDDSB-HBYCUIHISA-N
Gene Information
human ... EBP(10682)
General description
Application
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC), powder | description Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo. | description Cyclopamine- KAAD, CAS 306387-90-6, is a cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM). |
| form solid | form powder | form solid | form solid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥70% (sum of two isomers, HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: soluble ≥5 mg/mL, H2O: insoluble | solubility methanol: >2 mg/mL, H2O: insoluble | solubility DMF: 10 mg/mL, DMSO: 4 mg/mL, ethanol: 5 mg/mL | solubility ethanol: 1 mg/mL, methanol: 1 mg/mL, DMSO: 5 mg/mL |
| color white | color - | color off-white | color white to light yellow |
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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