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C4231

モノクローナル抗β-カテニン, リン酸化型(pSer³³/pSer³⁷)抗体マウス宿主抗体

Name: モノクローナル抗β-カテニン, リン酸化型(pSer<SUP>33</SUP>/pSer<SUP>37</SUP>)抗体 マウス宿主抗体
Brand: SIGMA
Price: 120000 JPY

clone BC-22, purified from hybridoma cell culture

別名:

Anti-CTNNB, Anti-EVR7, Anti-MRD19, Anti-NEDSDV, Anti-armadillo

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あなたへ/カタログ番号	在庫状況	単価
0.2 mL	カートの在庫状況を確認する	￥120,000

この商品について

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03457566

Conjugate:

unconjugated

Clone:

BC-22, monoclonal

Application:

ARR, ELISA (i), WB

Citations:

￥120,000

カートの在庫状況を確認する

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特性

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BC-22, monoclonal

form

buffered aqueous solution

mol wt

antigen ~94 kDa

species reactivity

mouse, human, rat, chicken

concentration

~2 mg/mL

technique(s)

indirect ELISA: suitable, microarray: suitable, western blot: 5-10 μg/mL using whole cell extract of cultured human 293 cells treated with proteasome inhibitor MG132

isotype

IgG2b

UniProt accession no.

P35222

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer33/pSer37)

Gene Information

human ... CTNNB1(1499)
mouse ... Ctnnb1(12387)
rat ... Ctnnb1(84353)

詳細

General description

CTNNB1 (catenin β 1) gene is mapped to human chromosome 3p21. The encoded protein β-catenin is localized to the nucleus.

Immunogen

ヒトβ-カテニンのセリン33および37を含む領域に相当する合成リン酸化ペプチド。

Application

Monoclonal Anti-phospho-β-Catenin (pSer33/pSer37) antibody is suitable for:

indirect ELISA
microarray[1]
western blot at a dilution of 5-10μg/mL using whole cell extract of cultured human 293 cells treated with proteasome inhibitor MG132.

Biochem/physiol Actions

pSer³³ペプチドよりもpSer³⁷ペプチドの方が効果的に抗体を阻害し、非リン酸化ペプチドの場合は阻害されません。非リン酸化型またはSer³³リン酸化型のタンパク質は検出されません。また、リン酸化型プラコグロビンも認識しません。

β-catenin is mapped on the short arm of chromosome 3. It is useful for differential diagnosis of Osteoblastoma (OB) and osteosarcoma (OS). β-catenin signaling pathway may contribute to cholangiocarcinoma (CCA) cell proliferation. It may serve as a prognostic marker for CCA progression and hence can be significant in the CCA therapy target.
In Wnt/β-catenin signal pathway β-Catenin participates as a signal transduction molecule. The pathway is associated with development, tissue homeostasis and oncogenic transcription. Upregulation of the gene is associated with glioma cell proliferation. The protein encoded has dual function that regulates the coordination of cell-cell adhesion by linking cytoskeleton and cellular junctions and gene transcription. Wnt/β-catenin signal pathway is known to induce progression colon cancer progression.

Physical form

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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当該品目	SAB4200720	C2363	C8616
Sigma-Aldrich C4231 モノクローナル抗β-カテニン, リン酸化型(pSer³³/pSer³⁷)抗体マウス宿主抗体	Sigma-Aldrich SAB4200720 Anti-β-Catenin antibody, Mouse monoclonal	Sigma-Aldrich C2363 モノクローナル抗β-カテニン, リン酸化型(pSer³³)抗体マウス宿主抗体	Sigma-Aldrich C8616 Monoclonal Anti-phospho-β-Catenin (pThr⁴¹) antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone BC-22, monoclonal	clone 15B8, monoclonal	clone BC-76, monoclonal	clone BCT-41, monoclonal
antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form purified immunoglobulin
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity mouse, human, rat, chicken	species reactivity chicken, mouse, human, rat, monkey, hamster, bovine, canine	species reactivity human	species reactivity human
Gene Information human ... CTNNB1(1499) mouse ... Ctnnb1(12387) rat ... Ctnnb1(84353)	Gene Information human ... CTNNB1(1499) mouse ... Ctnnb1(12387) rat ... Ctnnb1(84353)	Gene Information human ... CTNNB1(1499)	Gene Information human ... CTNNB1(1499)

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保管分類

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c