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C4899

Carnitine Acetyltransferase from pigeon breast muscle

ammonium sulfate suspension, ≥50 units/mg protein

Synonym(s):

CATC, Carnitine acetyltransferase, Acetyl-Co-A:carnitine-O-acetyltransferase, CrAT

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Size/SKUAvailabilityPrice
1 mg

Estimated to ship onAugust 05, 2026fromSAINT LOUIS

$184.00
5 mg

Estimated to ship onAugust 05, 2026fromSAINT LOUIS

$529.00
10 mg

Estimated to ship onAugust 05, 2026fromSAINT LOUIS

$912.00

About This Item

CAS Number:
9029-90-7
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
2.3.1.7 (BRENDA, IUBMB)
MDL number:
MFCD00130725
Specific activity:
≥50 units/mg protein
Biological source:
pigeon breast
Concentration:
≥0.4 mg/mL

$184.00

Estimated to ship onAugust 05, 2026Details

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biological source

pigeon breast

Quality Segment

200

form

ammonium sulfate suspension

specific activity

≥50 units/mg protein

concentration

≥0.4 mg/mL

technique(s)

cell based assay: suitable

Protein ID accession no.

AAA80570.1

UniProt accession no.

P52826

storage temp.

2-8°C

Gene Information

pigeon ... CRAT(102084317)

General description

Research area: Cell Signaling

Application

Carnitine Acetyltransferase from pigeon breast muscle has been used in enzymatic assays.

Biochem/physiol Actions

Carnitine acyltransferases (CrAT) are enzymes that contribute to the reversible conversion of acetyl-CoA and carnitine into acetylcarnitine and free CoA. This enzymatic process plays a vital role in the energy metabolism of eukaryotes by promoting the β-oxidation of fatty acids. CrAT-mediated acetyl carnitine production and efflux help maintain a balance between acetyl-CoA and acetyl carnitine in the mitochondria, regenerate free CoA, and alleviate the product inhibition of pyruvate dehydrogenase (PDH), which is a key enzyme in glucose oxidation. This process promotes glucose homeostasis and helps maintain optimal cellular energy metabolism. Carnitine acetyltransferase activity also aids in the progression of the cell cycle from G1 to S phase. carnitine acetyltransferase deficiency also leads to the development of various neurological disorders including Alzheimer′s disease, ataxic encephalopathy, and several vascular diseases.
Carnitine acetyltransferase maintains the cellular and mitochondrial levels of acetyl-CoA, a key cofactor required for oxidative metabolism, by catalyzing an equilibrium between acetyl-CoA and acetyl-L-carnitine, a storage form of activated acetate. Carnitine acetyltransferase also maintains the pool of acetyl-CoA required for neuronal and nonneuronal acetylcholine production.

Physical form

Crystalline suspension in 3.2 M (NH4)2SO4 solution, 50 mM potassium phosphate, 1 mM dithiothreitol, pH 7.0

Analysis Note

Protein determined by biuret.

Other Notes

One unit will convert 1.0 μmole of acetyl-L-carnitine and CoA to L-carnitine and acetyl-CoA per min at pH 8.0 at 25 °C.

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description

ammonium sulfate suspension, ≥50 units/mg protein

description

Type III-S, ammonium sulfate suspension, ≥4,000 units/mg protein

description

Type II, ammonium sulfate suspension, 350-600 units/mg protein

description

Type I, ammonium sulfate suspension, 100-300 units/mg protein

specific activity

≥50 units/mg protein

specific activity

≥4,000 units/mg protein

specific activity

350-600 units/mg protein

specific activity

100-300 units/mg protein

technique(s)

cell based assay: suitable

technique(s)

-

technique(s)

ligand binding assay: suitable

technique(s)

activity assay: suitable

biological source

pigeon breast

biological source

rabbit muscle

biological source

rabbit muscle

biological source

rabbit muscle

Gene Information

pigeon ... CRAT(102084317)

Gene Information

-

Gene Information

-

Gene Information

-

concentration

≥0.4 mg/mL

concentration

-

concentration

-

concentration

-

form

ammonium sulfate suspension

form

ammonium sulfate suspension

form

ammonium sulfate suspension

form

ammonium sulfate suspension

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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