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Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse

Name: Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse
Brand: SIGMA
Price: 1090 USD
Availability: InStock

clone 42705.111, purified immunoglobulin, lyophilized powder

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Size/SKU	Availability	Price
0.5 mg	Estimated to ship onAugust 17, 2026fromMILWAUKEE	$1,090.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD02096157

Conjugate:

unconjugated

Clone:

42705.111, monoclonal

Application:

FACS, IHC (f), Neutral

Citations:

$1,090.00

Estimated to ship onAugust 17, 2026Details

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Properties

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

42705.111, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: 10 μg/mL using using human blood cells (10 μL diluted antibody/10⁵-10⁶cells), immunohistochemistry (frozen sections): 25 μg/mL using human tissue (speen), neutralization: suitable

isotype

IgG2a

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL8RA(3577)
mouse ... Il8ra(227288)

Description

General description

Chemokine receptor CXCR1 also refers as type I IL-8 receptor or IL-8RA is a class A, rhodopsin-like G-protein-coupled receptor, expressed mainly in neutrophils but not in T or B lymphocytes . It has a crucial role in cellular signal transduction and targeted as drug receptors. Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used to neutralize the bioactivity facilitated by human cell surface CXCR-1. Mouse anti-CXCR-1 (IL-8 RA) antibody reacts specifically with CXCR-1 transfected cells but not with the parent cell line. The product has also shown no cross-reactivity with human CXCR-2.

Immunogen

human CXCR1 transfected NSO mouse myeloma cells.

Application

Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used in flow cytometry for detecting CXCR-1 present on human blood cells. It can also be used in immunohistochemistry (25 μg/mL) using frozen human tissue sections (spleen).

Biochem/physiol Actions

The antiboody, in the presence of anti-CXCR2 (Sigma Product No. C6348), will neutralize human cell surface CXCR-1 mediated-myloperoxidase release from human granulocytes induced by IL-8. The antibody reacts with human CXCR1 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR2.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

1 of 1

This Item	C6473	F3668	C8352
Sigma-Aldrich C6223 Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse	Sigma-Aldrich C6473 Monoclonal Anti-CXCR3 antibody produced in mouse	Sigma-Aldrich F3668 Monoclonal Anti-CD16−FITC antibody produced in mouse	$Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich C8352 Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit
description clone 42705.111, purified immunoglobulin, lyophilized powder	description clone 49801.111, purified immunoglobulin, lyophilized powder	description clone 3G8, purified immunoglobulin, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution
Gene Information human ... IL8RA(3577) mouse ... Il8ra(227288)	Gene Information human ... CXCR3(2833) mouse ... Cxcr3(12766)	Gene Information human ... FCGR3A(2214), FCGR3B(2215)	Gene Information human ... CXCR4(7852)
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form IgG fraction of antiserum
conjugate unconjugated	conjugate unconjugated	conjugate FITC conjugate	conjugate unconjugated
species reactivity human	species reactivity human	species reactivity human	species reactivity human
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
clone 42705.111, monoclonal	clone 49801.111, monoclonal	clone 3G8, monoclonal	clone polyclonal

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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