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Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse

Name: Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse
Brand: SIGMA
Price: 1170 USD
Availability: InStock

clone 42705.111, purified immunoglobulin, lyophilized powder

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Size/SKU	Availability	Price
0.5 mg	Estimated to ship onOctober 05, 2026fromMILWAUKEE	$1,170.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD02096157

Conjugate:

unconjugated

Clone:

42705.111, monoclonal

Application:

FACS, IHC (f), Neutral

Citations:

$1,170.00

Estimated to ship onOctober 05, 2026Details

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Properties

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

42705.111, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: 10 μg/mL using using human blood cells (10 μL diluted antibody/10⁵-10⁶cells), immunohistochemistry (frozen sections): 25 μg/mL using human tissue (speen), neutralization: suitable

isotype

IgG2a

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL8RA(3577)
mouse ... Il8ra(227288)

Description

General description

Chemokine receptor CXCR1 also refers as type I IL-8 receptor or IL-8RA is a class A, rhodopsin-like G-protein-coupled receptor, expressed mainly in neutrophils but not in T or B lymphocytes . It has a crucial role in cellular signal transduction and targeted as drug receptors. Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used to neutralize the bioactivity facilitated by human cell surface CXCR-1. Mouse anti-CXCR-1 (IL-8 RA) antibody reacts specifically with CXCR-1 transfected cells but not with the parent cell line. The product has also shown no cross-reactivity with human CXCR-2.

Immunogen

human CXCR1 transfected NSO mouse myeloma cells.

Application

Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used in flow cytometry for detecting CXCR-1 present on human blood cells. It can also be used in immunohistochemistry (25 μg/mL) using frozen human tissue sections (spleen).

Biochem/physiol Actions

The antiboody, in the presence of anti-CXCR2 (Sigma Product No. C6348), will neutralize human cell surface CXCR-1 mediated-myloperoxidase release from human granulocytes induced by IL-8. The antibody reacts with human CXCR1 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR2.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

1 of 1

This Item	C6473	C6348	ABN1449
Sigma-Aldrich C6223 Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse	Sigma-Aldrich C6473 Monoclonal Anti-CXCR3 antibody produced in mouse	Sigma-Aldrich C6348 Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse	Sigma-Aldrich ABN1449 Anti-CXCR-4
description clone 42705.111, purified immunoglobulin, lyophilized powder	description clone 49801.111, purified immunoglobulin, lyophilized powder	description clone 48311, purified immunoglobulin, lyophilized powder	description from rabbit, purified by affinity chromatography
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone 42705.111, monoclonal	clone 49801.111, monoclonal	clone 48311, monoclonal	clone polyclonal
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form affinity isolated antibody
species reactivity human	species reactivity human	species reactivity human	species reactivity human
Gene Information human ... IL8RA(3577) mouse ... Il8ra(227288)	Gene Information human ... CXCR3(2833) mouse ... Cxcr3(12766)	Gene Information human ... IL8RB(3579) mouse ... Il8rb(12765)	Gene Information human ... CXCR4(7852)
biological source mouse	biological source mouse	biological source mouse	biological source rabbit

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Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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