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C6303

Calphostin C

From microbial (Cladosporium cladosporioides), ≥90% (HPLC), protein kinase C inhibitor, powder

Synonym(s):

UCN-1028c

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0.1 mg

Available to ship TODAYfromMILWAUKEE

$467.00
1 mg

Available to ship TODAYfromMILWAUKEE

$2,130.00

About This Item

Empirical Formula (Hill Notation):
C44H38O14
CAS Number:
Molecular Weight:
790.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:

$467.00


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Product Name

Calphostin C from Cladosporium cladosporioides, ≥90% (HPLC), powder

biological source

microbial (Cladosporium cladosporioides)

Quality Segment

assay

≥90% (HPLC)

form

powder

color

red to brown

solubility

DMF: 1 mg/mL, DMSO: 1 mg/mL, ethanol: 1 mg/mL

storage temp.

−20°C

SMILES string

COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24

InChI

1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3

InChI key

SRJYZPCBWDVSGO-UHFFFAOYSA-N

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

Features and Benefits

This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
P2141T4540T3694
description

≥90% (HPLC), powder

description

≥90%

description

-

description

-

biological source

microbial (Cladosporium cladosporioides)

biological source

Amanita phalloides

biological source

Streptomyces sp.

biological source

-

assay

≥90% (HPLC)

assay

≥90%

assay

-

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

-

solubility

DMSO: 1 mg/mL, DMF: 1 mg/mL, ethanol: 1 mg/mL

solubility

-

solubility

methanol: soluble 4.90-5.10 mg/mL, clear (Pale yellow to yellow), methanol: soluble 4.90-5.10 mg/mL, clear, pale yellow to yellow

solubility

H2O: soluble

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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