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C6305

Clozapine

≥98% (TLC), powder, D₄-dopamine receptor antagonist

Synonym(s):

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$121.00
100 mg

Estimated to ship onJanuary 04, 2027fromMILWAUKEE

$398.00
1 g

Available to ship TODAY

$2,210.00

About This Item

Empirical Formula (Hill Notation):
C18H19ClN4
CAS Number:
Molecular Weight:
326.82
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder

$121.00


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Product Name

Clozapine,

form

powder

Quality Segment

solubility

ethanol: 1 mg/mL, 0.1 M HCl: 30 mg/mL, DMSO: 4.8 mg/mL

originator

Novartis

SMILES string

CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key

QZUDBNBUXVUHMW-UHFFFAOYSA-N

Biochem/physiol Actions

Atypical antipsychotic compound. Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item
1142107BP905PHR3655
Clozapine British Pharmacopoeia (BP) Reference Standard

BP905

Clozapine

description

-

description

United States Pharmacopeia (USP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

description

certified reference material, pharmaceutical secondary standard

form

powder

form

-

form

solid

form

-

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

300

solubility

DMSO: 4.8 mg/mL, 0.1 M HCl: 30 mg/mL, ethanol: 1 mg/mL

solubility

-

solubility

-

solubility

-

originator

Novartis

originator

-

originator

-

originator

-

Gene Information

human ... ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HRH4(59340), HTR2A(3356), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR6(3362), HTR7(3363), KCNH1(3756), KCNH2(3757), UGT1A4(54657)
rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Chrm1(25229), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2b(29581), Htr2c(25187), Htr3a(79246), Htr7(65032), Slc6a4(25553)

Gene Information

human ... DRD2(1813), HTR2A(3356)

Gene Information

human ... DRD2(1813), HTR2A(3356)

Gene Information

-


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Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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