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Monoclonal Anti-Connexin-32 antibody produced in mouse

Name: Monoclonal Anti-Connexin-32 antibody produced in mouse
Brand: SIGMA
Price: 845 USD
Availability: InStock

clone CXN-32, ascites fluid, buffered aqueous solution

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$845.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00803531

Conjugate:

unconjugated

Clone:

CXN-32, monoclonal

Application:

ARR, ELISA (i), IHC (f), WB

Citations:

$845.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CXN-32, monoclonal

form

buffered aqueous solution

mol wt

antigen 27 kDa

contains

15 mM sodium azide

species reactivity

human, rat, mouse

technique(s)

immunohistochemistry (frozen sections): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1:1,000 using a mouse whole brain extract

isotype

IgG1

UniProt accession no.

P08034

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GJB1(2705), GJB2(2706)
mouse ... Gjb1(14618)
rat ... Gja1(24392), Gjb1(29584)

Description

General description

Monoclonal Anti-Connexin-32 (mouse IgG1 isotype) is derived from the CXN-32 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The 27 kDa connexin protein (Connexin-32, Cx32), belongs to the connexion family of proteins. It is expressed in most tissues, even though the pattern of expression may differ in various cell types including peripheral and central nervous system.

Immunogen

synthetic connexin-32 peptide (amino acids 105-123).

Application

Monoclonal Anti-Connexin-32 antibody produced in mouse has been used in:

enzyme linked immunosorbent assay (ELISA)
immunoblotting
epifuorescent microscopy

Biochem/physiol Actions

Connexin-32 low expression levels is observed in common bile duct ligation (CBDL). In addition, a combination of myelin disruption and axonal degeneration has been shown to occur with Cx32 mutations in Charcot-Marie-Tooth disease (CMTX). Monoclonal antibodies reacting specifically with Cx32, may be used in diverse cellular and molecular approaches to the study of gap junctions and their properties, and to correlate their expression pattern with physiological functions or pathological conditions.

Connexins belong to the gap junction protein family. In humans, connexin is encoded by GJB1 (gap junction protein, β 1) gene. The gap junction proteins connexin32 (Cx32), Cx37, Cx40 and Cx43 are expressed in endothelial cells and regulate vascular functions involving inflammation. The endothelial Cx32 positively regulates angiogenesis by enhancing endothelial cell tube formation and cell migration. CX32 mutation is associated with cognitive impairment and a differential degree of peripheral nerve involvement.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	C3595	C8093	SAB4200730
Sigma-Aldrich C6344 Monoclonal Anti-Connexin-32 antibody produced in mouse	Sigma-Aldrich C3595 Anti-Connexin-32 (106-124) antibody produced in rabbit	Sigma-Aldrich C8093 Monoclonal Anti-Connexin-43 antibody produced in mouse	Sigma-Aldrich SAB4200730 Anti-Connexin 43 antibody, Mouse monoclonal
description clone CXN-32, ascites fluid, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description clone CXN-6, ascites fluid	description clone CXN-6, hybridoma cell culture supernatant
antibody form ascites fluid	antibody form affinity isolated antibody	antibody form ascites fluid	antibody form culture supernatant
species reactivity human, rat, mouse	species reactivity mouse, human, rat	species reactivity rat, hamster, bovine, mouse, human	species reactivity chicken, rat, feline, bovine, human, porcine, mouse
Gene Information human ... GJB1(2705), GJB2(2706) mouse ... Gjb1(14618) rat ... Gja1(24392), Gjb1(29584)	Gene Information human ... GJB1(2705) mouse ... Gjb1(14618) rat ... Gjb1(29584)	Gene Information human ... GJA1(2697), GJA1P1(2698) mouse ... Gja1(14609) rat ... Gja1(24392)	Gene Information bovine ... Gja1(281193) cat ... Gja1(101100211) chicken ... Gja1(395278) human ... GJA1(2697) mouse ... Gja1(14609) rat ... Gja1(24392)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
clone CXN-32, monoclonal	clone polyclonal	clone CXN-6, monoclonal	clone CXN-6, monoclonal
biological source mouse	biological source rabbit	biological source mouse	biological source mouse

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c