Key Documents

View All Documentation

Monoclonal Anti-Connexin-32 antibody produced in mouse

Name: Monoclonal Anti-Connexin-32 antibody produced in mouse
Brand: SIGMA

clone CXN-32, ascites fluid, buffered aqueous solution

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00803531

Conjugate:

unconjugated

Clone:

CXN-32, monoclonal

Application:

ARR, ELISA (i), IHC (f), WB

Citations:

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CXN-32, monoclonal

form

buffered aqueous solution

mol wt

antigen 27 kDa

contains

15 mM sodium azide

species reactivity

human, rat, mouse

technique(s)

immunohistochemistry (frozen sections): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1:1,000 using a mouse whole brain extract

isotype

IgG1

UniProt accession no.

P08034

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GJB1(2705), GJB2(2706)
mouse ... Gjb1(14618)
rat ... Gja1(24392), Gjb1(29584)

Description

General description

Monoclonal Anti-Connexin-32 (mouse IgG1 isotype) is derived from the CXN-32 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The 27 kDa connexin protein (Connexin-32, Cx32), belongs to the connexion family of proteins. It is expressed in most tissues, even though the pattern of expression may differ in various cell types including peripheral and central nervous system.

Immunogen

synthetic connexin-32 peptide (amino acids 105-123).

Application

Monoclonal Anti-Connexin-32 antibody produced in mouse has been used in:

enzyme linked immunosorbent assay (ELISA)
immunoblotting
epifuorescent microscopy

Biochem/physiol Actions

Connexin-32 low expression levels is observed in common bile duct ligation (CBDL). In addition, a combination of myelin disruption and axonal degeneration has been shown to occur with Cx32 mutations in Charcot-Marie-Tooth disease (CMTX). Monoclonal antibodies reacting specifically with Cx32, may be used in diverse cellular and molecular approaches to the study of gap junctions and their properties, and to correlate their expression pattern with physiological functions or pathological conditions.

Connexins belong to the gap junction protein family. In humans, connexin is encoded by GJB1 (gap junction protein, β 1) gene. The gap junction proteins connexin32 (Cx32), Cx37, Cx40 and Cx43 are expressed in endothelial cells and regulate vascular functions involving inflammation. The endothelial Cx32 positively regulates angiogenesis by enhancing endothelial cell tube formation and cell migration. CX32 mutation is associated with cognitive impairment and a differential degree of peripheral nerve involvement.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	C8093	SAB4200730	C6219
Sigma-Aldrich C6344 Monoclonal Anti-Connexin-32 antibody produced in mouse	Sigma-Aldrich C8093 Monoclonal Anti-Connexin-43 antibody produced in mouse	Sigma-Aldrich SAB4200730 Anti-Connexin 43 antibody, Mouse monoclonal	Sigma-Aldrich C6219 Anti-Connexin-43 antibody produced in rabbit
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
antibody form ascites fluid	antibody form ascites fluid	antibody form culture supernatant	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate unconjugated
species reactivity human, rat, mouse	species reactivity rat, hamster, bovine, mouse, human	species reactivity chicken, rat, feline, bovine, human, porcine, mouse	species reactivity mammals, human
Gene Information human ... GJB1(2705), GJB2(2706) mouse ... Gjb1(14618) rat ... Gja1(24392), Gjb1(29584)	Gene Information human ... GJA1(2697), GJA1P1(2698) mouse ... Gja1(14609) rat ... Gja1(24392)	Gene Information bovine ... Gja1(281193) cat ... Gja1(101100211) chicken ... Gja1(395278) human ... GJA1(2697) mouse ... Gja1(14609) rat ... Gja1(24392)	Gene Information human ... GJA1(2697) mouse ... Gja1(14609) rat ... Gja1(24392)
clone CXN-32, monoclonal	clone CXN-6, monoclonal	clone CXN-6, monoclonal	clone polyclonal

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c