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Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse

Name: Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse
Brand: SIGMA
Price: 801 USD

clone 48311, purified immunoglobulin, lyophilized powder

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Pack Size	SKU	Availability	Price
0.5 mg		Check Cart for Availability	$801.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD01864633

Conjugate:

unconjugated

Clone:

48311, monoclonal

Application:

FACS, Neutral

Citations:

$801.00

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Properties

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

48311, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: suitable, neutralization: suitable

isotype

IgG2a

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL8RB(3579)
mouse ... Il8rb(12765)

Description

General description

The antibody will neutralize human cell surface CXCR-2 mediated-myloperoxidase release from human granulocytes induced by GROα. It will not block myeloperoxidase release induced by IL-8. The antibody reacts with human CXCR-2 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR-1.

Immunogen

human CXCR2 transfected NSO mouse myeloma cells.

Biochem/physiol Actions

CXCR2 is a G protein-coupled receptor that binds IL-8 with high affinity. It mediates migration of neutrophils to the sites of inflammation. It also binds CXCL1 and stimulates growth of melanomas.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

1 of 1

This Item	C6473	C6223	I6784
Sigma-Aldrich C6348 Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse	Sigma-Aldrich C6473 Monoclonal Anti-CXCR3 antibody produced in mouse	Sigma-Aldrich C6223 Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse	Sigma-Aldrich I6784 Monoclonal Anti-Interleukin-2 antibody produced in mouse
biological source mouse	biological source mouse	biological source mouse	biological source mouse
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... IL8RB(3579) mouse ... Il8rb(12765)	Gene Information human ... CXCR3(2833) mouse ... Cxcr3(12766)	Gene Information human ... IL8RA(3577) mouse ... Il8ra(227288)	Gene Information human ... IL2(3558)
clone 48311, monoclonal	clone 49801.111, monoclonal	clone 42705.111, monoclonal	clone 5334, monoclonal
species reactivity human	species reactivity human	species reactivity human	species reactivity human

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healing.

Snjezana Zaja-Milatovic et al.

Histology and histopathology, 23(11), 1399-1407 (2008-09-12)

Wound healing requires a complex series of reactions and interactions among cells and their mediators, resulting in an overlapping series of events including coagulation, inflammation, epithelialization, formation of granulation tissue, matrix and scar formation. Cytokines and chemokines promote inflammation, angiogenesis

Role of chemokines in the biology of natural killer cells.

Michael J Robertson

Journal of leukocyte biology, 71(2), 173-183 (2002-01-31)

Natural killer (NK) cells participate in innate and adaptive immune responses to obligate intracellular pathogens and malignant tumors. Two major NK cell subsets have been identified in humans: CD56(dim) CD16+ and CD56(bright) CD16-. Resting CD56(dim) CD16+ NK cells express CXCR1

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+ NKT cells in chemically induced IFN-γ-mediated skin inflammation.

Chia-Yuan Hsieh et al.

Journal of immunology (Baltimore, Md. : 1950), 193(7), 3693-3703 (2014-08-31)

IFN-γ mediates chemically induced skin inflammation; however, the mechanism by which IFN-γ-producing cells are recruited to the sites of inflammation remains undefined. Secretion of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, from damaged cells may promote immune cell recruitment.

Global Trade Item Number

SKU	GTIN
C6348-.5MG	04061832714035

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