Skip to Content
MilliporeSigma

Key Documents

Skip To

C6706

Z-Leu-Leu-Norvalinal

≥90% (HPLC), powder

Promotion Available

Synonym(s):

MG115, Z-LLnV

Sign In to View Organizational & Contract Pricing.

Spend $500 — Save 5%; Spend $750 — Save 10%; Spend $1,000 — Save 22%*

Sign in to check eligibility. Shop Products

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$335.00

About This Item

Empirical Formula (Hill Notation):
C25H39N3O5
CAS Number:
Molecular Weight:
461.59
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32

$335.00

Save Up To 22%


Available to ship TODAYDetails


​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥90% (HPLC)

form

powder

color

white

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O

InChI

1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1

InChI key

QEJRGURBLQWEOU-FKBYEOEOSA-N

Gene Information

Biochem/physiol Actions

Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
474780C221172517
description

≥90% (HPLC), powder

description

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

description

≥90% (HPLC)

description

≥99.0% (HPLC)

form

powder

form

solid

form

powder

form

powder

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥99.0% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

color

white

color

white

color

white

color

-

solubility

DMSO: soluble

solubility

DMSO: 50 mg/mL

solubility

DMSO: soluble

solubility

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters