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C7268

Chymostatin

powder

Synonym(s):

N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)

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1 mg

Available to ship TODAYfromMILWAUKEE

$72.30
5 mg

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$186.00
25 mg

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$671.00
50 mg

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$1,240.00
100 mg

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$2,380.00

About This Item

CAS Number:
9076-44-2
UNSPSC Code:
12352202
PubChem Substance ID:
329775144
NACRES:
NA.77
MDL number:
MFCD00071059

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Product Name

Chymostatin, microbial

biological source

microbial

Quality Segment

form

powder

input

general use sample(s)

solubility

DMSO: 10 mM (Stock solutions stable for months at −20 °C.)

storage temp.

−20°C

SMILES string

OC(C(NC(NC(C1NC(NCC1)=N)C([F,Cl,Br,I]C)=O)=O)CC2=CC=CC=C2)=O

InChI key

MRXDGVXSWIXTQL-HYHFHBMOSA-N

Application

Chymostatin has been used in a study that determined that molecular calculations are useful for evaluating the interactions between ligands, including inhibitors and homologous enzymes, in docking models. Chymostatin has also been used in a study to investigate the norovirus protease as an attractive target for antiviral drug development.

Biochem/physiol Actions

Inhibits the lysosomal proteinase cathepsin B, and the soluble Ca2+-activated proteinase. Many young plant tissues express a chomostatin-sensitive serine protease.
Chymostatin is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, B, H, and L. It weakly inhibits human leucocyte elastase. It is effective at a final concentration of 100 to 200 μg/ml (10 to 100 μM). Chymostatin is often included in protease inhibitor cocktails used with plant extracts.

Preparation Note

Solubility testing in glacial acetic acid at 10 mg/ml yields a clear solution, which is usually colorless, but can be yellow in appearance. It is reportedly also soluble in DMSO; only slightly soluble in water and short-chain alcohols; insoluble in ethyl acetate, butyl acetate, ether, hexane, and petroleum ether. Stock solutions (10 mM) can be prepared in DMSO and are stable for months at -20 °C. Stock solutions can also be made in 0.1 M HCl. Dilute solutions (10-100 μM) are only stable for several hours, due to oxidation of the terminal aldehyde.

Other Notes

A mixture of A (major), B and C components. A: X=Leu; B: X=Val; C: X=Ile
chymostatin A MW = 607.7
chymostatin B MW = 593.7
chymostatin C MW = 607.7

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Thymol solution certified reference material, 2000 μg/mL in methanol, ampule of 1 mL

Supelco

CRM40188

Thymol solution

description

microbial

description

-

description

-

description

certified reference material, 2000 μg/mL in methanol, ampule of 1 mL

biological source

microbial

biological source

-

biological source

-

biological source

-

Quality Level

300

Quality Level

-

Quality Level

100

Quality Level

300

form

powder

form

powder

form

-

form

liquid

solubility

DMSO: 10 mM (Stock solutions stable for months at −20 °C.)

solubility

acetic acid: soluble 20 mg/mL

solubility

-

solubility

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

input

general use sample(s)

input

-

input

-

input

-

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Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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