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C7464

Monoclonal Anti-Cyclin D1 antibody produced in mouse

clone DCS-6, ascites fluid

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0.5 mL

Available to ship TODAYfromMILWAUKEE

$659.00
$560.15

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00239664
Conjugate:
unconjugated
Clone:
DCS-6, monoclonal
Application:
ARR, ICC, IHC (f), IHC (p), IP, WB
Citations:
25

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

DCS-6, monoclonal

mol wt

antigen 36 kDa (several lower and higher molecular weight bands)

contains

15 mM sodium azide

species reactivity

rat, mouse, human, monkey

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, microarray: suitable, western blot: 1:200 using a human tumor cell line extract

isotype

IgG2a

UniProt accession no.

P24385

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCND1(595)
mouse ... Ccnd1(12443)
rat ... Ccnd1(58919)

General description

Monoclonal Anti-Cyclin D1 (mouse IgG2a isotype) is derived from the DCS-6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Cyclin D1 protein is a G1-phase cyclin in mammalian cells. This protein is a D-type cyclin. The CCD1 gene is located on the human chromosome at 11q13.3.

Immunogen

recombinant human Cyclin D1 protein.

Application

Monoclonal Anti-Cyclin D1 antibody produced in mouse may be used in:
  • immunoblotting[1]
  • immunofluorescence[2]
  • immunocytochemistry
  • immunoprecipitation
  • immunohistochemistry[3]
  • antibody-mediated knock-out experiments

Biochem/physiol Actions

Cyclin D1 is involved in regulating cyclin-dependent kinase (CDK) family members. Cyclin D1 and D2 are affiliated with CDK4 and/or CDK6 kinase activities that are observed in mid-G1 and culminate in the late G1 phase. Amplification of the cyclin D1 gene is observed in a significant percentage of cancers, including breast, bladder carcinoma, mantle cell lymphomas, head and neck cancers. This gene is also amplified in esophageal squamous cell carcinomas.
Does not cross-react with other D-type cyclins.

Physical form

The product is provided as ascites fluid with 15 mM sodium azide as a preservative.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Monoclonal Anti-Cyclin D1 antibody produced in mouse clone DCS-6, ascites fluid

Sigma-Aldrich

C7464

Monoclonal Anti-Cyclin D1 antibody produced in mouse

Monoclonal Anti-Cyclin D1 antibody produced in mouse clone DCS-6

Sigma-Aldrich

SAB4700958

Monoclonal Anti-Cyclin D1 antibody produced in mouse

Monoclonal Anti-p19INK4d antibody produced in mouse clone DCS-100, ascites fluid

Sigma-Aldrich

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Anti-Cyclin D1 antibody, Rabbit monoclonal recombinant, expressed in proprietary host, clone SP4, tissue culture supernatant

Sigma-Aldrich

SAB5500090

Anti-Cyclin D1 antibody, Rabbit monoclonal

clone

DCS-6, monoclonal

clone

DCS-6, monoclonal

clone

DCS-100, monoclonal

clone

SP4, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

tissue culture supernatant

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rabbit

Gene Information

human ... CCND1(595)
mouse ... Ccnd1(12443)
rat ... Ccnd1(58919)

Gene Information

human ... CCND1(595)

Gene Information

human ... CDKN2D(1032)

Gene Information

human ... CCND1(595)

species reactivity

rat, mouse, human, monkey

species reactivity

rat, nonhuman primates, human, mouse

species reactivity

human

species reactivity

human (tested)

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000511813
0000511813
0000512397
0000368975
0000303607

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Related Content

H Nakagawa et al.
Cancer, 76(4), 541-549 (1995-08-15)
Oncogene activation and tumor suppressor gene inactivation have been implicated in the genetic basis of esophageal squamous cell carcinoma (ESCC). Cyclin D1, an oncogene that has a critical role in G1 progression of the cell cycle, has been observed to
Takeshi Shimamura et al.
Cancer research, 65(14), 6401-6408 (2005-07-19)
Somatic mutations in the kinase domain of the epidermal growth factor receptor (EGFR), including L858R and exon 19 deletions, underlie responsiveness to gefitinib and erlotinib in non-small cell lung cancer (NSCLC). Acquired resistance to these tyrosine kinase inhibitors is in
Huei-Tzu Chien et al.
Cancers, 11(6) (2019-06-05)
Oral squamous cell carcinoma (OSCC) is a common cancer in Taiwan and worldwide. To provide some clues for clinical management of OSCC, 72 advanced-stage OSCCs were analyzed using two microarray platforms (26 cases with Affymetrix 500 K and 46 cases
View All Related Papers

Global Trade Item Number

SKUGTIN
C7464-.5ML04061837867859

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