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Anti-Calretinin antibody produced in rabbit

Name: Anti-Calretinin antibody produced in rabbit
Brand: SIGMA
Price: 574 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CAB29, Anti-CAL2, Anti-CR

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$574.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.44

MDL number:

MFCD01321794

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (p), WB

Citations:

$574.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 29 kDa

species reactivity

rat, human, chicken

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using formalin-fixed, paraffin-embedded rat cerebellum sections, microarray: suitable, western blot: 1:1,000 using recombinant human calretinin

UniProt accession no.

P22676

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CALB2(794)
rat ... Calb2(117059)

Description

General description

Anti-Calretinin is developed in rabbit using a synthetic peptide corresponding to the C-terminal region of rat calretinin (amino acids 194-209) conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Calretinin is an intracellular Ca²⁺-binding protein, with broad tissue distribution and is a member of the calmodulin superfamily. It is expressed in certain populations of neurons in the central and peripheral nervous systems. It is abundant in the cerebellum (granule cells), olfactory bulb and auditory pathways.

Immunogen

synthetic peptide corresponding to the C-terminal region of rat calretinin (amino acids 194-209) conjugated to KLH. This sequence is specific for calretinin and not found in other members of the EF-hand family such as calbindin-D-28K, calbindin-D-9K, myosin light chain, parvalbumin, S-100a, S-100b, S100A2 (S100L) and S100A6 (calcyclin). This sequence is identical in human and mouse calretinin and highly conserved in chicken calretinin.

Application

Anti-Calretinin antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.

Anti-Calretinin antibody produced in rabbit is suitable for the following applications:

immunohistochemistry
microarray
western blotting at a dilution of 1:1,000 using recombinant human calretinin

Biochem/physiol Actions

The physiological function of calretinin is not known, but it seems to be related to Ca²⁺ buffering and diffusion. Calretinin-deficient mice show impaired long-term potentiation (LTP) in the dentate gyrus, impaired motor coordination and Purkinje cell excitability. A role for both calretinin and calbindin-D-28K in synaptic plasticity and in neuroprotection from excitotoxic insults has been postulated. By acting as a buffer or sensor of intracellular free Ca²⁺, calretinin promotes calcium homeostasis. Furthermore, several truncated forms of calretinin have been found in certain tumor cells, but are absent from normal cells, suggesting that calretinin may play a role in tumorigenesis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB5500031	MAB1568	HPA007305
Sigma-Aldrich C7479 Anti-Calretinin antibody produced in rabbit	Sigma-Aldrich SAB5500031 Anti-Calretinin antibody, Rabbit monoclonal	Sigma-Aldrich MAB1568 Anti-Calretinin Antibody, clone 6B8.2	Sigma-Aldrich HPA007305 Anti-CALB2 antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description recombinant, expressed in proprietary host, clone SP13, tissue culture supernatant	description clone 6B8.2, Chemicon^®, from mouse	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form tissue culture supernatant	antibody form purified immunoglobulin	antibody form affinity isolated antibody
species reactivity rat, human, chicken	species reactivity human (tested)	species reactivity mouse, rat	species reactivity human
technique(s) microarray: suitable, western blot: 1:1,000 using recombinant human calretinin, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using formalin-fixed, paraffin-embedded rat cerebellum sections	technique(s) immunohistochemistry: 1:100	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:5000-1:10000, immunofluorescence: 0.25-2 μg/mL

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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