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Citalopram hydrobromide

Name: Citalopram hydrobromide
Brand: SIGMA
Price: 196 USD
Availability: InStock

≥98% (HPLC), powder, serotonin uptake inhibitor

Synonym(s):

1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide

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Size/SKU	Availability	Price
10 mg	Check Cart for Availability	$196.00
50 mg	Check Cart for Availability	$831.00

About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁FN₂O · HBr

CAS Number:

59729-32-7

Molecular Weight:

405.30

NACRES:

NA.77

PubChem Substance ID:

24278335

UNSPSC Code:

12352200

EC Number:

261-890-6

MDL number:

MFCD02101306

Assay:

≥98% (HPLC)

Form:

powder

$196.00

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Properties

Product Name

Citalopram hydrobromide, ≥98% (HPLC)

Quality Segment

200

assay

≥98% (HPLC)

form

powder

solubility

chloroform: soluble, methanol: soluble

originator

Forest Labs

storage temp.

2-8°C

SMILES string

Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H

InChI key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

Description

General description

Citalopram is a bicyclic phthalene derivative. It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment. It is used to treat obsessive compulsive disorder, panic disorder, sociophobia and premenstrual dysphoric disorder.

Application

Citalopram hydrobromide has been used:

to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice
to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats
for 5-hydroxytryptamine (5-HT) competition uptake assays

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Features and Benefits

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	Y0001008	BP1153	Y0000855
Sigma-Aldrich C7861 Citalopram hydrobromide	Y0001008 Citalopram hydrobromide	BP1153 Citalopram hydrobromide	Y0000855 Citalopram for system suitability
description ≥98% (HPLC)	description European Pharmacopoeia (EP) Reference Standard	description British Pharmacopoeia (BP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard
form powder	form -	form solid	form -
assay ≥98% (HPLC)	assay -	assay -	assay -
Quality Level 200	Quality Level -	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility chloroform: soluble, methanol: soluble	solubility -	solubility -	solubility -
Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)	Gene Information human ... SLC6A4(6532)	Gene Information human ... SLC6A4(6532)	Gene Information human ... SLC6A4(6532)

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Pictograms

GHS08,GHS07

Signal Word

Warning

Hazard Codes

H302,H336,H361d,H412

Precautionary Statements

P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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