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Anti-Connexin 43 Antibody

Name: Anti-Connexin 43 Antibody
Brand: SIGMA

mouse monoclonal, CXN-6

Synonym(s):

Mouse monoclonal antibody

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00803532

Conjugate:

unconjugated

Clone:

CXN-6, monoclonal

Application:

ARR, ELISA (i), ICC, IHC (f), IHC (p), WB

Citations:

Pricing and availability is not currently available.

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Properties

Product Name

Monoclonal Anti-Connexin-43 antibody produced in mouse, clone CXN-6, ascites fluid

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CXN-6, monoclonal

mol wt

antigen 43 kDa

contains

15 mM sodium azide

species reactivity

rat, hamster, bovine, mouse, human

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1:8,000-1:16.000 using mouse whole brain extract

isotype

IgM

UniProt accession no.

P17302

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GJA1(2697), GJA1P1(2698)
mouse ... Gja1(14609)
rat ... Gja1(24392)

Description

General description

Monoclonal Anti-Connexin-43 (mouse IgM isotype) is derived from the CXN-6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Connexin 43 (Cx43) is also known as GJA1 (gap junction protein alpha 1). The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops and a C-terminal cytoplasmic tail of varying length.

The 43 kDa connexin protein (connexin-43, Cx43) belongs to the a-type (group II) subfamily of connexin proteins. It is expressed in most tissues, even though the pattern of expression may differ in various cell types. For example, in the brain it is found in astrocytes, ependyma and leptomeninges but not in neurons, oligodendrocytes and pinealocytes; in the liver it is present in Ito cells but not hepatocytes.

Immunogen

synthetic connexin-43 peptide (362-381).

Application

Monoclonal Anti-Connexin-43 antibody produced in mouse has been used in:

fluorescent immunostaining
western blotting
immunocytochemistry
preparation of immuno-affinity columns

Biochem/physiol Actions

Monoclonal Anti-Connexin-43 reacts specifically with connexin-43. Reactivity has been observed with human, bovine, hamster, rat, and mouse connexin-43.

Mutations in connexin 43 (Cx43) gene result in pleiotropic phenotype of oculodentodigital dysplasia. Connexin 43 participates in the multiplication and differentiation of mature T cells. It also participates in the secretion and manufacturing of cytokines. It helps to release lactate from glycolytic pancreatic ductal adenocarcinoma cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200730	C6344	SAB4200819
Sigma-Aldrich C8093 Monoclonal Anti-Connexin-43 antibody produced in mouse	Sigma-Aldrich SAB4200730 Anti-Connexin 43 antibody, Mouse monoclonal	Sigma-Aldrich C6344 Monoclonal Anti-Connexin-32 antibody produced in mouse	Sigma-Aldrich SAB4200819 Anti-Connexin 43 antibody, Mouse monoclonal
description clone CXN-6, ascites fluid	description clone CXN-6, hybridoma cell culture supernatant	description clone CXN-32, ascites fluid, buffered aqueous solution	description clone CXN-6, purified from hybridoma cell culture
antibody form ascites fluid	antibody form culture supernatant	antibody form ascites fluid	antibody form purified from hybridoma cell culture
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity rat, hamster, bovine, mouse, human	species reactivity chicken, rat, feline, bovine, human, porcine, mouse	species reactivity human, rat, mouse	species reactivity porcine, feline, chicken, mouse, human, rat
conjugate unconjugated	conjugate -	conjugate unconjugated	conjugate -
Gene Information human ... GJA1(2697), GJA1P1(2698) mouse ... Gja1(14609) rat ... Gja1(24392)	Gene Information bovine ... Gja1(281193) cat ... Gja1(101100211) chicken ... Gja1(395278) human ... GJA1(2697) mouse ... Gja1(14609) rat ... Gja1(24392)	Gene Information human ... GJB1(2705), GJB2(2706) mouse ... Gjb1(14618) rat ... Gja1(24392), Gjb1(29584)	Gene Information Porcine ... GJA1(100518636) chicken ... GJA1(395278) feline ... GJA1(101100211) human ... GJA1(2697) mouse ... GJA1(14609) rat ... GJA1(24392)
clone CXN-6, monoclonal	clone CXN-6, monoclonal	clone CXN-32, monoclonal	clone CXN-6, monoclonal

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c