The molecular weight for Product C8195, Complement C4 from human serum, is 205,000 daltons as described in Complement: A Practical Approach, A.W. Dodds and R.B. Sim, Eds., p. 2, 1997.
C8195
Complement C4 from human serum
≥300,000 C4H50 units/mg protein
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 0.1 mg | Please contact Customer Service for Availability | $641.00 |
About This Item
Form:
solution
Biological source:
human serum
General description
Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.
Application
Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.
Biochem/physiol Actions
There are strong indications that complement C4 deficiency is correlated with induction of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.
Physical form
Supplied as a solution in PBS, pH 7.2
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| technique(s) activity assay: suitable | technique(s) - | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| biological source human serum | biological source - | biological source human serum | biological source human serum |
| form solution | form liquid | form solution | form solution |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| specific activity ≥300,000 C4H50 units/mg protein | specific activity >3X105 C4H50 units/mg protein | specific activity ≥150,000 C7H50 units/mg protein | specific activity >100,000 C5H50 units/mg protein |
| Gene Information human ... C4A(720) | Gene Information - | Gene Information human ... C7(730) | Gene Information human ... C5(727) |
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
Instructions
Three novel single-nucleotide polymorphisms of complement component 4 gene (C4A) in Chinese Holstein cattle and their associations with milk performance traits and CH50.
Yang Y., et al.
Veterinary Immunology and Immunopathology (2011)
Schizophrenia risk from complex variation of complement component 4
Sekar A, et al.
Nature, 530(7589), 177-177 (2016)
Anti-MBL autoantibodies in patients with rheumatoid arthritis: prevalence and clinical significance
Gupta B, et al.
Journal of Autoimmunity, 27(2), 125-133 (2006)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C8195-.1MG | 04061833420317 |
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What is the molecular weight of Product C8195, Complement C4 from human serum?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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