Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

C8195

Complement C4 from human serum

≥300,000 C4H50 units/mg protein

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
0.1 mg
Check Cart for Availability
$546.00

About This Item

CAS Number:
80295-48-3
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00130838
Form:
solution
Biological source:
human serum

$546.00

Check Cart for Availability
​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

human serum

Quality Segment

form

solution

specific activity

≥300,000 C4H50 units/mg protein

technique(s)

activity assay: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... C4A(720)

General description

Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.

Application

Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.

Biochem/physiol Actions

There are strong indications that complement C4 deficiency is correlated with induction of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.

Physical form

Supplied as a solution in PBS, pH 7.2

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
C3535D9321CLS354008
Complement C4 from human serum ≥300,000 C4H50 units/mg protein

Sigma-Aldrich

C8195

Complement C4 from human serum

Complement C8 from human serum suitable for radioiodination, RIA, ≥85% (SDS-PAGE), ≥125,000 C8H50 units/mg protein (using C8 deficient serum)

Sigma-Aldrich

C3535

Complement C8 from human serum

D-dimer, Human from human plasma, buffered aqueous solution

Sigma-Aldrich

D9321

D-dimer, Human

Corning® Fibronectin from human, pack of 1 mg

CLS354008

Corning® Fibronectin

description

≥300,000 C4H50 units/mg protein

description

suitable for radioiodination, RIA, ≥85% (SDS-PAGE), ≥125,000 C8H50 units/mg protein (using C8 deficient serum)

description

from human plasma, buffered aqueous solution

description

from human, pack of 1 mg

biological source

human serum

biological source

human

biological source

human plasma

biological source

human

technique(s)

activity assay: suitable

technique(s)

immunoelectrophoresis: suitable

technique(s)

-

technique(s)

-

form

solution

form

solution

form

buffered aqueous solution

form

-

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

shipped in

-

Gene Information

human ... C4A(720)

Gene Information

human ... C8A(731)

Gene Information

-

Gene Information

-

specific activity

≥300,000 C4H50 units/mg protein

specific activity

≥125,000 C8H50 units/mg protein (using C8 deficient serum)

specific activity

-

specific activity

-

Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

1–3 of 3 Questions  

  1. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  2. What is the molecular weight of Product C8195, Complement C4 from human serum?

    1 answer

    1. The molecular weight for Product C8195, Complement C4 from human serum, is 205,000 daltons as described in Complement: A Practical Approach, A.W. Dodds and R.B. Sim, Eds., p. 2, 1997.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

Reviews

No rating value

Active Filters