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C8655

4-Chloro-L-phenylalanine

Tryptophan hydroxylase inhibitor, powder

Synonym(s):

L-PCPA

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Size/SKUAvailabilityPrice
250 mg

Available to ship TODAYfromMILWAUKEE

$405.00
1 g

Available to ship TODAYfromMILWAUKEE

$755.00

About This Item

Linear Formula:
ClC6H4CH2CH(NH2)CO2H
CAS Number:
14173-39-8
Molecular Weight:
199.63
NACRES:
NA.32
PubChem Substance ID:
24893091
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
238-023-5
MDL number:
MFCD00063065
Beilstein/REAXYS Number:
2416150
Form:
powder

$405.00

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Product Name

4-Chloro-L-phenylalanine,

form

powder

Quality Segment

mp

263 °C (dec.) (lit.)

storage temp.

−20°C

SMILES string

N[C@@H](Cc1ccc(Cl)cc1)C(O)=O

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1

InChI key

NIGWMJHCCYYCSF-QMMMGPOBSA-N

Gene Information

Application

4-Chloro-L-phenylalanine (L-PCPA) has been used:
  • to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH)
  • to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio)
  • as a substrate for Chromobacterium violaceum phenylalanine hydroxylase
  • to incubate sea urchin embryos for immunohistochemistry

Biochem/physiol Actions

4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.
Tryptophan hydroxylase inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
0919317755360279
4-Chloro-L-phenylalanine

Sigma-Aldrich

C8655

4-Chloro-L-phenylalanine

4-Amino-L-phenylalanine hydrochloride ≥96.0% (calc. on dry substance, AT)

Sigma-Aldrich

09193

4-Amino-L-phenylalanine hydrochloride

4-Borono-L-phenylalanine ≥95.0% (HPLC)

Sigma-Aldrich

17755

4-Borono-L-phenylalanine

4-Nitro-L-phenylalanine monohydrate 98%

Sigma-Aldrich

360279

4-Nitro-L-phenylalanine monohydrate

description

-

description

≥96.0% (calc. on dry substance, AT)

description

≥95.0% (HPLC)

description

98%

form

powder

form

powder

form

-

form

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

Gene Information

human ... TPH1(7166), TPH2(121278)
mouse ... TPH1(21990), TPH2(216343)
rat ... TPH1(24848), TPH2(317675)

Gene Information

-

Gene Information

-

Gene Information

-

mp

263 °C (dec.) (lit.)

mp

-

mp

-

mp

245-251 °C (dec.) (lit.)

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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