The solubility of this product has been tested in chloroform at a concentration of 50 mg/mL. For cell culture application, it can be dissolved in fresh, anhydrous DMSO at 5 mg/mL (10.56 mM), but the final concentration of DMSO in cell culture should not exceed more than 0.1%. Most cells can tolerate up to 0.1% DMSO; however, the response may vary depending on the specific type of cell or cell line. Therefore, it is advisable to conduct preliminary testing to determine the optimal concentration for your particular application.
C8895
Clofazimine
≥98% (TLC), powder, antimycobacterial rimonphenazine
Synonym(s):
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Check Cart for Availability | $63.60 |
5 g | Check Cart for Availability | $222.00 |
About This Item
Empirical Formula (Hill Notation):
C27H22Cl2N4
CAS Number:
Molecular Weight:
473.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
217-980-2
MDL number:
Form:
powder
Product Name
Clofazimine,
form
powder
Quality Segment
antibiotic activity spectrum
mycobacteria
mode of action
protein synthesis | interferes
originator
Novartis
SMILES string
CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
InChI
1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
InChI key
WDQPAMHFFCXSNU-BGABXYSRSA-N
General description
Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.
Application
Clofazimine has been used:
- for antimicrobial preparation
- to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
- to model drug-induced hepatic granulomatous inflammation
- to study the in vivo cargo storage capacity of macrophages
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
This product is stored at room temperature.
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This Item | |||
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| description - | description European Pharmacopoeia (EP) Reference Standard | description United States Pharmacopeia (USP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard |
| form powder | form - | form - | form solid |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
| originator Novartis | originator - | originator - | originator - |
| antibiotic activity spectrum mycobacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
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Storage Class
11 - Combustible Solids
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What is the recommended solvent that is compatible for in vitro culture of mammalian cells?
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At what temperature should this be stored? I so not see a specified temperature on label or SDS so I would assume room temperature but other manufacturers of this product claim -20C
1 answer-
This product is stored at room temperature.
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