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C9124

CK-869

≥98% (HPLC), actin assembly inhibitor, powder

Synonym(s):

2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone, CK 869, CK-0157869

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$134.00
25 mg

Available to ship TODAYfromMILWAUKEE

$396.00
$336.60

About This Item

Empirical Formula (Hill Notation):
C17H16BrNO3S
CAS Number:
Molecular Weight:
394.28
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$134.00


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Product Name

CK-869, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to light gray

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br

InChI

1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3

InChI key

MVWNPZYLNLATCH-UHFFFAOYSA-N

Application

CK-869 has been used as an Arp2/3 complex inhibitor:
  • to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
  • to induce membrane blebbing in HT1080 fibrosarcoma cells
  • to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Biochem/physiol Actions

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

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This Item
C7374
description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: ≥20 mg/mL

color

white to light gray

color

peach to light pink


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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