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C9369

CCT007093

≥98% (HPLC), powder, yellow

Synonym(s):

(2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$362.00

About This Item

Empirical Formula (Hill Notation):
C15H12OS2
CAS Number:
176957-55-4
Molecular Weight:
272.39
NACRES:
NA.77
PubChem Substance ID:
329775204
UNSPSC Code:
12352200
MDL number:
MFCD00121546
Assay:
≥98% (HPLC)
Form:
powder, yellow

$362.00

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Quality Segment

100

assay

≥98% (HPLC)

form

powder, yellow

solubility

DMSO: >3 mg/mL

storage temp.

2-8°C

SMILES string

O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3

InChI

1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+

InChI key

KPFZCKDPBMGECB-WGDLNXRISA-N

Application

CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.

Biochem/physiol Actions

CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.
CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines.
CCT007093 is an effective protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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CCT007093 ≥98% (HPLC), powder, yellow

Sigma-Aldrich

C9369

CCT007093

NSC 617145 ≥98% (HPLC)

Sigma-Aldrich

SML1005

NSC 617145

BLT-1 ≥98% (HPLC)

Sigma-Aldrich

SML0059

BLT-1

L48H37 ≥98% (HPLC)

Sigma-Aldrich

SML1443

L48H37

description

≥98% (HPLC), powder, yellow

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder, yellow

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >3 mg/mL

solubility

DMSO: 3 mg/mL, clear (warmed)

solubility

DMSO: ≥13 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

CCT007093 research chemical for UV stress assays

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-

-

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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