C9979
Monoclonal Anti-CD152 antibody produced in mouse
~1 mg/mL, clone AS32, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-CTLA-4
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 0.1 mg | Please contact Customer Service for Availability | $1,050.00 |
About This Item
Conjugate:
unconjugated
Clone:
AS32, monoclonal
Application:
Neutral, WB
Citations:
4
$1,050.00
Please contact Customer Service for Availability
A recombinant, preservative-free antibody is available for your target. Try ZRB1783
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
AS32, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
neutralization: suitable, western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... CTLA4(1493)
General description
CD152 is structurally similar to CD28 and is a member of the immunoglobin (Ig) gene superfamily. The gene encoding human CD152 is present on chromosone 2. It is composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. It is mainly expressed by cytotoxic T lymphocytes and the level of expression is activation-dependent.
CD152, a cell surface glycoprotein, is one of two ligands (the other is CD28) for CD80 (B7-1) and CD86 (B7-2). This interaction appears to function as a negative regulator to T cell activation. CD152 is transiently expressed on activated T cells.
Immunogen
recombinant extracellular domain of human CD152.
Application
Monoclonal Anti-CD152 antibody produced in mouse is suitable for western blotting and for neutralization studies, where this antibody has been shown to block the interaction of soluble human CD152 with human CD80.
Biochem/physiol Actions
CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
Preparation Note
Prepared from tissue culture supernatant, purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| clone AS32, monoclonal | clone BNI3, monoclonal | clone MEM-158, monoclonal | clone HI186, monoclonal |
| species reactivity human | species reactivity human | species reactivity human | species reactivity human |
| Gene Information human ... CTLA4(1493) | Gene Information human ... CTLA4(1493) | Gene Information human ... FUT4(2526) | Gene Information human ... CD52(1043) |
| antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form purified immunoglobulin |
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
Datasheet
Danbee Ha et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(2), 609-618 (2018-12-28)
Anti-CTLA-4 mAb is efficacious in enhancing tumor immunity in humans. CTLA-4 is expressed by conventional T cells upon activation and by naturally occurring FOXP3+CD4+ Treg cells constitutively, raising a question of how anti-CTLA-4 mAb can differentially control these functionally opposing
N J Karandikar et al.
The Journal of experimental medicine, 184(2), 783-788 (1996-08-01)
CTLA-4, a CD28 homologue expressed on activated T cells, binds with high affinity to the CD28 ligands, B7-1 (CD80) and B7-2 (CD86). This study was designed to examine the role of CTLA-4 in regulating autoimmune disease. Murine relapsing-remitting experimental autoimmune
T Lindsten et al.
Journal of immunology (Baltimore, Md. : 1950), 151(7), 3489-3499 (1993-10-01)
CTLA-4 is an adhesion receptor expressed on activated T cells. The amino acid sequence of CTLA-4 is related to CD28, and although the function of CTLA-4 remains unknown, it shares several features with CD28, including a common counter-receptor, B7, that
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C9979-.1MG | 04061838172501 |