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Monoclonal Anti-CD152 antibody produced in mouse

Name: Monoclonal Anti-CD152 antibody produced in mouse
Brand: SIGMA
Price: 3060 PLN

~1 mg/mL, clone AS32, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-CTLA-4

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Size/SKU	Availability	Price
0.1 mg	Please contact Customer Service for Availability	3.060,00 PLN

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01864928

Conjugate:

unconjugated

Clone:

AS32, monoclonal

Application:

Neutral, WB

Citations:

3.060,00 PLN

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AS32, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

neutralization: suitable, western blot: suitable

isotype

IgG1

UniProt accession no.

P16410

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CTLA4(1493)

Description

General description

CD152 is structurally similar to CD28 and is a member of the immunoglobin (Ig) gene superfamily. The gene encoding human CD152 is present on chromosone 2. It is composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. It is mainly expressed by cytotoxic T lymphocytes and the level of expression is activation-dependent.

CD152, a cell surface glycoprotein, is one of two ligands (the other is CD28) for CD80 (B7-1) and CD86 (B7-2). This interaction appears to function as a negative regulator to T cell activation. CD152 is transiently expressed on activated T cells.

Immunogen

recombinant extracellular domain of human CD152.

Application

Monoclonal Anti-CD152 antibody produced in mouse is suitable for western blotting and for neutralization studies, where this antibody has been shown to block the interaction of soluble human CD152 with human CD80.

Biochem/physiol Actions

CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.

Preparation Note

Prepared from tissue culture supernatant, purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4700924	SAB4700789	SAB4700815
Sigma-Aldrich C9979 Monoclonal Anti-CD152 antibody produced in mouse	Sigma-Aldrich SAB4700924 Monoclonal Anti-CD152 antibody produced in mouse	Sigma-Aldrich SAB4700789 Monoclonal Anti-CD15 antibody produced in mouse	Sigma-Aldrich SAB4700815 Monoclonal Anti-CD122 antibody produced in mouse
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone AS32, monoclonal	clone BNI3, monoclonal	clone MMA, monoclonal	clone TU27, monoclonal
species reactivity human	species reactivity human	species reactivity human	species reactivity human
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... CTLA4(1493)	Gene Information human ... CTLA4(1493)	Gene Information human ... FUT4(2526)	Gene Information human ... IL2RB(3560)

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c