This product is water-soluble and can be dissolved in water-based solvents, including artificial cerebrospinal fluid (aCSF). The solubility in water has been tested at concentrations > 5 mg/mL. The material is also soluble in DMSO at approximately 3 mg/mL and ethanol at approximately 2 mg/mL. Prepared solutions may be stored for approximately 24 hours at 4 °C, protected from light.
D054
R(+)-SCH-23390 hydrochloride
≥98% (HPLC), dopamine receptor antagonist, solid
Synonym(s):
R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Check Cart for Availability | $126.00 | |
| 10 mg | Check Cart for Availability | $205.00 | |
| 25 mg | Check Cart for Availability | $549.00 | |
| 100 mg | Check Cart for Availability | $1,730.00 |
About This Item
Empirical Formula (Hill Notation):
C17H18ClNO · HCl
CAS Number:
Molecular Weight:
324.24
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
R(+)-SCH-23390 hydrochloride, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]/D +32.1°, c = 1 in DMF(lit.)
storage condition
desiccated, protect from light
color
white
solubility
H2O: >5 mg/mL
SMILES string
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
Gene Information
human ... DRD1(1812)
Application
R(+)-SCH-23390 hydrochloride has been used:
- for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
- as a D1 receptor-selective antagonist for intracranial drug infusions
- as an antagonist of D1 receptor to study its effect on learning ability in fish
Biochem/physiol Actions
R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.
Features and Benefits
This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Sold with the permission of Schering-Plough.
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This Item | |||
|---|---|---|---|
| form solid | form crystalline | form solid | form solid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: >5 mg/mL | solubility H2O: >5 mg/mL, aqueous base: soluble (unstable) | solubility H2O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL | solubility H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble |
| storage condition desiccated, protect from light | storage condition desiccated, protect from light | storage condition desiccated | storage condition - |
| optical activity [α]/D +32.1°, c = 1 in DMF(lit.) | optical activity - | optical activity - | optical activity - |
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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L C Iorio et al.
The Journal of pharmacology and experimental therapeutics, 226(2), 462-468 (1983-08-01)
SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in
Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
Messias Joao PM, et al.
Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. Royal Society (Great Britain), 283(1823), 20152272-20152272 (2016)
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Meririnne E, et al.
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D054-25MG | 04061833557815 |
| D054-5MG | 04061833557822 |
| D054-100MG | 04061832090108 |
| D054-10MG | 04061833557808 |
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Can you dissolve Product D054, R(+)-SCH-23390 hydrochloride in aCSF?
1 answer-
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What is the solution stability of Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
Solutions may be stored for approximately 24 hours at 2-8 °C, protected from exposure to light.
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Is Product D054, R(+)-SCH-23390 hydrochloride, only selective for the D1 dopamine receptor antagonist?
1 answer-
The D054 is a selective D1 dopamine receptor antagonist, but is also selective to the D5.
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What is the melting point of Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
The melting point is 247-248°C.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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How do I dissolve Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
The D054 is tested for solublity in water at > 5 mg/mL. The product is also reported to be soluble in DMSO at 3mg/mL, and in ethanol at 2 mg/mL.
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Is Product D054, R(+)-SCH-23390 hydrochloride, light sensitive?
1 answer-
Yes, D054 is light sensitive. The powder form of the product, as well as solutions of the product, need to be protected from light.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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