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D1413

2′,3′-Didehydro-3′-deoxythymidine

≥98% (TLC)

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Synonym(s):

1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine, 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-(1H,3H)-dione, 2′,3′-Anhydrothymidine, Stavudine, d4T

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$112.00
50 mg

Available to ship TODAYfromMILWAUKEE

$389.00

About This Item

Empirical Formula (Hill Notation):
C10H12N2O4
CAS Number:
3056-17-5
Molecular Weight:
224.21
NACRES:
NA.77
PubChem Substance ID:
24278356
UNSPSC Code:
12352200
MDL number:
MFCD00132921
Assay:
≥98% (TLC)
Form:
powder

$112.00

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Quality Segment

assay

≥98% (TLC)

form

powder

storage temp.

−20°C

SMILES string

CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O

InChI

1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1

InChI key

XNKLLVCARDGLGL-JGVFFNPUSA-N

General description

2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.

Application

2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.

Biochem/physiol Actions

2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.

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This Item
1620209Y0000421Y0000408
2′,3′-Didehydro-3′-deoxythymidine ≥98% (TLC)

Sigma-Aldrich

D1413

2′,3′-Didehydro-3′-deoxythymidine

Stavudine United States Pharmacopeia (USP) Reference Standard

USP

1620209

Stavudine

Stavudine for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000421

Stavudine for system suitability

Stavudine European Pharmacopoeia (EP) Reference Standard

Y0000408

Stavudine

description

≥98% (TLC)

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

assay

≥98% (TLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000081235
    0000095768
    0000161731
    0000301501
    0000320030

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