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D1634

Diosgenin

≥93%, apoptosis inducer, powder

Synonym(s):

(25R)-5-Spirosten-3β-ol, 3β-Hydroxy-5-spirostene, Nitogenin

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5 g

Available to ship TODAYfromMILWAUKEE

$75.40
100 g

Available to ship TODAYfromMILWAUKEE

$832.00
$707.20

About This Item

Empirical Formula (Hill Notation):
C27H42O3
CAS Number:
512-04-9
Molecular Weight:
414.62
NACRES:
NA.77
PubChem Substance ID:
24893501
UNSPSC Code:
12352200
EC Number:
208-134-3
MDL number:
MFCD00016887
Beilstein/REAXYS Number:
94582
Assay:
≥93%
Form:
powder
Quality level:
200

$75.40

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Product Name

Diosgenin, ≥93%

Quality Level

200

assay

≥93%

form

powder

SMILES string

[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2

InChI

1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1

InChI key

WQLVFSAGQJTQCK-VKROHFNGSA-N

Gene Information

human ... UGT1A4(54657)

General description

Diosgenin is a triterpene and a glycone derivative of dioscin. Yams, Trigonella foenum-graecum and Costus speciosus are some of its source.

Application

Diosgenin has been:
  • used as a standard in the analysis of total saponins in Sapindus rarak
  • orally administered to the rats to study its role against atherogenic diet-induced production of inflammatory mediators in heart, liver and brain
  • used as a standard compound to determine the saponins content in chickpea and Tribulus terrestris[1]

Biochem/physiol Actions

Diosgenin induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and cyclooxygenase activity in osteosarcoma cells. It serves as a precursor in steroid drug production. Diosgenin is shown to promote cholesterol production by stimulating biliary excretion. It influences lipoxygenase induced human erythroleukemia cell line differentiation.

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This Item
PHL89649Y0001871D7321
Diosgenin ≥93%

Sigma-Aldrich

D1634

Diosgenin

Diosgenin phyproof® Reference Substance

PHL89649

Diosgenin

Diosgenin European Pharmacopoeia (EP) Reference Standard

Y0001871

Diosgenin

Diosmetin

Sigma-Aldrich

D7321

Diosmetin

assay

≥93%

assay

≥98.0% (HPLC)

assay

-

assay

≥98% (HPLC)

form

powder

form

solid

form

-

form

powder

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

200

Gene Information

human ... UGT1A4(54657)

Gene Information

-

Gene Information

-

Gene Information

-

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000495746
0000495746
0000493068
0000493068
0000492996

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Chung-Hsiung Huang et al.
Journal of natural products, 73(6), 1033-1037 (2010-05-15)
It was hypothesized that the suppressive effect of diosgenin (1) on the intestinal T helper (Th)2 responses is associated with an enhancement of the regulatory T-cell immunity. Ovalbumin (OVA)-sensitized BALB/c mice were gavaged daily with 1 and received repeatedly oral
Gautam Sethi et al.
Nutrients, 10(5) (2018-05-23)
Novel and alternative options are being adopted to combat the initiation and progression of human cancers. One of the approaches is the use of molecules isolated from traditional medicinal herbs, edible dietary plants and seeds that play a pivotal role
Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats
Son IS, et al.
Bioscience, Biotechnology, and Biochemistry, 71(12), 3063-3071 (2007)
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Global Trade Item Number

SKUGTIN
D1634-5G04061835556458
D1634-100G04061833560334

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