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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Available to ship TODAY | $276.00 |
100 mg | Available to ship TODAY | $827.00 |
About This Item
Empirical Formula (Hill Notation):
C6H12F2N2O2 · xHCl · yH2O
CAS Number:
Molecular Weight:
182.17 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97% (NMR)
Form:
solid
$276.00
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Product Name
DL-α-Difluoromethylornithine hydrochloride hydrate, solid, ≥97% (NMR)
Quality Segment
assay
≥97% (NMR)
form
solid
color
white
solubility
DMSO: >10 mg/mL, H2O: >10 mg/mL
SMILES string
O.Cl.NCCCC(N)(C(F)F)C(O)=O
InChI
1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChI key
FJPAMFNRCFEGSD-UHFFFAOYSA-N
Gene Information
human ... ODC1(4953)
General description
Difluoromethylornithine is a fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.
Application
Biochem/physiol Actions
Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.
Inhibits polyamine biosynthesis by selective, irreversible inhibition of ornithine decarboxylase. Chemoprotective agent that blocks angiogenesis.
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This Item | ||
|---|---|---|
| description solid, ≥97% (NMR) | description 98% | description ≥99% |
| assay ≥97% (NMR) | assay 98% | assay ≥99% |
| form solid | form - | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level 200 |
| solubility DMSO: >10 mg/mL, H2O: >10 mg/mL | solubility - | solubility - |
| color white | color - | color - |
| Gene Information human ... ODC1(4953) | Gene Information - | Gene Information - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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