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Merck

D3072

Doxycycline Hydrochloride, Ready Made Solution

100 mg/mL in DMSO, ≥95.0% (HPLC)

Synonym(s):

α-6-Deoxy-5-hydroxytetracycline hydrochloride, 2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-, Doxylin, Idocyklin, Vibramycin hyclate, Vibramycin hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H24N2O8 · HCl
CAS Number:
10592-13-9
Molecular Weight:
480.90
NACRES:
NA.85
UNSPSC Code:
51284028
MDL number:
MFCD03427564

Key Documents

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biological source

synthetic

Quality Level

200

sterility

0.22 μm filtered

assay

≥95.0% (HPLC)

form

liquid

concentration

100 mg/mL in DMSO

solubility

DMSO: 100 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

mode of action

protein synthesis | interferes

storage temp.

−20°C

InChI

1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1

InChI key

VLUQVUWDECWBTL-UQVCFKGQSA-N

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General description

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Application

<ul>
<li><strong>AAPS PharmSciTech: </strong>Creation of a PVA/PCL/CS-based nanofibrous membrane incorporating doxycycline hydrochloride for guided tissue regeneration and controlled delivery in the management of periodontitis, evaluated in vivo in rats (Mirzaeei et al., 2024).</li>
<li><strong>European Journal of Pharmacology: </strong>Doxycycline hydrochloride′s role in inhibiting the progression of malignant rhabdoid tumor of the kidney by targeting MMP17 and MMP1 through the PI3K-Akt signaling pathway (Mi et al., 2024).</li>
</ul>

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
0000419621
0000419621
0000408895
0000408895
0000366924

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Global Trade Item Number

SKUGTIN
D3072-1ML04061833562932

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