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D3816

Anti-Drebrin antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-developmentally-regulated brain protein

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200 μL
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$587.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.46
MDL number:
MFCD03845304
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
12

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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat

technique(s)

western blot: 1:1,000 using rat brain cytosol extract, western blot: 1:1,000 using whole extract of the human epitheloid carcinoma HeLa cell line

UniProt accession no.

Q16643

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DBN1(1627)
rat ... Dbn1(81653)

General description

Drebrin is a member of the newly identified ADF-H family of actin-binding proteins that share the structurally conserved actin-depolymerizing factor (ADF) binding module. It is composed of a single ADF-H domain at its N-terminus, followed by a non-conserved central region and a C-terminal SH3 domain. Three isoforms, E1 and E2 (embryonic) and A (adult), have been identified in the brain. An additional truncated form of drebrin A, s-drebrin/A2, is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.

Immunogen

synthetic peptide corresponding to the N-terminal region of human drebrin E/A (amino acids 22-42) conjugated to KLH.

Biochem/physiol Actions

Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. It colocalizes with actin filaments and dendritic-like cell processes and may be involved in actin remodeling. It binds to and dissociates F-actin stabilizing proteins such as α-actinin, fascin, and tropomyosin from actin filaments. It plays an important role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

technique(s)

western blot: 1:1,000 using rat brain cytosol extract, western blot: 1:1,000 using whole extract of the human epitheloid carcinoma HeLa cell line

technique(s)

western blot: 1:2,000-1:4,000 using whole extracts of HeLa human epithelioid carcinoma and mouse NIH3T3 cells

technique(s)

microarray: suitable, western blot: 1:2,000 using a whole cell extract of the human epitheloid carcinoma HeLa cell line induced with interferon-γ

technique(s)

indirect immunofluorescence: 1:100 using Rat1 cells, western blot (chemiluminescent): 1:1,000 using whole extract of human HeLa cells, western blot (chemiluminescent): 1:2,000 using whole extract of mouse NIH3T3 cells

species reactivity

human, rat

species reactivity

mouse, human, pig (predicted), rat (predicted)

species reactivity

human

species reactivity

mouse, human, rat

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000547322
0000547322
0000525927
0000525927
0000506946

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Related Content

T Shirao et al.
Experimental cell research, 215(1), 145-153 (1994-11-01)
Drebrin A is a neuron-specific protein, the expression of which is regulated during development. Upon transfection of fibroblasts with drebrin A cDNA, the protein is expressed at high levels in fibroblasts and the outgrowth of highly branched, neurite-like cell processes
R Ishikawa et al.
The Journal of biological chemistry, 269(47), 29928-29933 (1994-11-25)
Drebrin is a development-associated neuroprotein whose cDNA into fibroblasts causes the formation of dendrite-like structures (Shirao, T., Kojima, N., and Obata, K. (1992) Neuroreport 3, 109-112). To explore molecular functions of drebrin during brain development, we purified drebrin from brains
H Asada et al.
Journal of neuroscience research, 38(2), 149-159 (1994-06-01)
Drebrins are developmentally regulated actin-binding proteins. In this study, we analyzed subcellular distribution of drebrin E in neuroblastoma cells (SH-SY5Y) in culture, especially in terms of its relationship to actin filaments. In undifferentiated cells, drebrin E was scattered as flocculus
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Global Trade Item Number

SKUGTIN
D3816-200UL04061837720185

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