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Anti-Drebrin antibody produced in rabbit

Name: Anti-Drebrin antibody produced in rabbit
Brand: SIGMA
Price: 587 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-developmentally-regulated brain protein

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$587.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD03845304

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$587.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat

technique(s)

western blot: 1:1,000 using rat brain cytosol extract, western blot: 1:1,000 using whole extract of the human epitheloid carcinoma HeLa cell line

UniProt accession no.

Q16643

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DBN1(1627)
rat ... Dbn1(81653)

Description

General description

Drebrin is a member of the newly identified ADF-H family of actin-binding proteins that share the structurally conserved actin-depolymerizing factor (ADF) binding module. It is composed of a single ADF-H domain at its N-terminus, followed by a non-conserved central region and a C-terminal SH3 domain. Three isoforms, E1 and E2 (embryonic) and A (adult), have been identified in the brain. An additional truncated form of drebrin A, s-drebrin/A2, is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.

Immunogen

synthetic peptide corresponding to the N-terminal region of human drebrin E/A (amino acids 22-42) conjugated to KLH.

Biochem/physiol Actions

Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. It colocalizes with actin filaments and dendritic-like cell processes and may be involved in actin remodeling. It binds to and dissociates F-actin stabilizing proteins such as α-actinin, fascin, and tropomyosin from actin filaments. It plays an important role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	AB10140	SAB4701043	SAB6012065
$Anti-Drebrin antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich D3816 Anti-Drebrin antibody produced in rabbit	Sigma-Aldrich AB10140 Anti-Drebrin A/E Antibody	Sigma-Aldrich SAB4701043 Monoclonal Anti-Drebrin antibody produced in mouse	SAB6012065 Anti Drebrin 1 Antibody, clone 23GB5145, Rabbit Monoclonal
description IgG fraction of antiserum, buffered aqueous solution	description from rabbit, purified by affinity chromatography	description clone DBN-N-03	description clone 23GB5145, recombinant rabbit monoclonal, expressed in HEK293 cells
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit (Monoclonal)
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 100
Gene Information human ... DBN1(1627) rat ... Dbn1(81653)	Gene Information human ... DBN1(1627)	Gene Information human ... DBN1(1627)	Gene Information human ... DBN1(1627)
technique(s) western blot: 1:1,000 using rat brain cytosol extract, western blot: 1:1,000 using whole extract of the human epitheloid carcinoma HeLa cell line	technique(s) immunocytochemistry: suitable, western blot: suitable	technique(s) flow cytometry: 2 μg/mL	technique(s) western blot: 1:1,000-1:5,000, flow cytometry: 1:2000

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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