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Devazepide

Name: Devazepide
Brand: SIGMA
Price: 235 USD
Availability: InStock

≥98% (HPLC), powder

Synonym(s):

(S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide, L-364,718, MK 329

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Size/SKU	Availability	Price
5 mg	Available to ship TODAYfromMILWAUKEE	$235.00
25 mg	Available to ship TODAYfromMILWAUKEE	$942.00

About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₀N₄O₂

CAS Number:

103420-77-5

Molecular Weight:

408.45

NACRES:

NA.77

PubChem Substance ID:

329798778

UNSPSC Code:

12352200

MDL number:

MFCD00864500

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >5 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c4ccccc4)c5ccccc15

InChI

1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1

InChI key

NFHRQQKPEBFUJK-HSZRJFAPSA-N

Description

General description

Devazepide is derived from asperlicin by chemical modification and has the benzodiazepine backbone.

Application

Devazepide has been used as a cholecystokinin receptor 1 (CCK1R) antagonist in human embryonic kidney 293T cells and in human pancreatic slices.

Biochem/physiol Actions

Devazepide is a cholecystokinin octapeptide (CCK1) (CCK-A) receptor antagonist. It inhibits CCK binding to peripheral-type receptor (CCK-A). Devazepide reverses the cholecystokinin octapeptide (CCK-8) based antagonism towards morphine.

Devazepide is a CCK1 (CCK-A) receptor antagonist and a CCK8 antagonist.

Devazepide is a CCK1 receptor antagonist.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item	Y0000123	1A08200	T1423000
Sigma-Aldrich D3821 Devazepide	Y0000123 Pidolic acid	USP 1A08200 Zolpidic Acid	T1423000 Ticlopidine hydrochloride
description ≥98% (HPLC), powder	description European Pharmacopoeia (EP) Reference Standard	description pharmaceutical analytical impurity (PAI)	description European Pharmacopoeia (EP) Reference Standard
form powder	form -	form -	form -
assay ≥98% (HPLC)	assay -	assay -	assay -
Quality Level 100	Quality Level -	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-30°C	storage temp. -
storage condition desiccated	storage condition -	storage condition -	storage condition -
solubility DMSO: >5 mg/mL	solubility -	solubility -	solubility -

Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H300

Precautionary Statements

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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