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D4434

Dichloromethylenediphosphonic acid disodium salt

osteoclastic activity inhibitor, powder

Synonym(s):

Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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Size/SKUAvailabilityPrice
1 g
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$383.00

About This Item

Linear Formula:
CH2O6Cl2Na2P2
CAS Number:
Molecular Weight:
288.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
245-078-9
MDL number:
Form:
powder

$383.00


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Product Name

Dichloromethylenediphosphonic acid disodium salt,

form

powder

Quality Segment

solubility

water: 49.00-51.00 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key

HJKBJIYDJLVSAO-UHFFFAOYSA-L

Gene Information

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

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This Item
D6899D3506233183
description

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description

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description

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description

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

form

powder

form

powder

form

powder or crystals

form

solid

Quality Level

300

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

solubility

water: 49.00-51.00 mg/mL, clear, colorless

solubility

methanol: 50 mg/mL, clear, colorless to faint yellow or tan

solubility

water: 1 g/10 mL, slightly hazy

solubility

water: 1 mg/mL

Gene Information

rat ... Man2a1(25478), Si(497756)

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Gene Information

-

Gene Information

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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