Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

D4526

Doxepin hydrochloride

≥98% (GC), norepinephrine uptake inhibitor, powder

Synonym(s):

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
1 g

Available to ship TODAYfromMILWAUKEE

$67.40
5 g

Available to ship TODAYfromMILWAUKEE

$261.00
$221.85

About This Item

Empirical Formula (Hill Notation):
C19H21NO · HCl
CAS Number:
1229-29-4
Molecular Weight:
315.84
NACRES:
NA.77
PubChem Substance ID:
24278093
UNSPSC Code:
12352200
EC Number:
214-966-8
MDL number:
MFCD00079135
Assay:
≥98% (GC)
Form:
powder
Quality level:
200

$67.40

Available to ship TODAYDetails

​
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder

Quality Level

200

assay

≥98% (GC)

form

powder

composition

Z-isomer, 15% , E-isomer, ~85%

color

white to off-white

solubility

1 M HCl: 50 mg/mL, H2O: soluble

originator

Boehringer Ingelheim

SMILES string

Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13

InChI

1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;

InChI key

MHNSPTUQQIYJOT-SJDTYFKWSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

General description

Doxepin is used to treat chronic idiopathic urticaria, chronic pain and anxiety. Doxepin exhibits antiserotonergic properties.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Mixture of cis- and trans-isomers

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
D-9271225500BP823
Doxepin hydrochloride ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder

Sigma-Aldrich

D4526

Doxepin hydrochloride

Doxepin hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-927

Doxepin hydrochloride solution

Doxepin hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1225500

Doxepin hydrochloride

Doxepin impurity standard British Pharmacopoeia (BP) Reference Standard

BP823

Doxepin impurity standard

form

powder

form

liquid

form

-

form

solid

assay

≥98% (GC)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

solubility

1 M HCl: 50 mg/mL, H2O: soluble

solubility

-

solubility

-

solubility

-

color

white to off-white

color

-

color

-

color

-

composition

Z-isomer, 15% , E-isomer, ~85%

composition

-

composition

-

composition

-

Still not finding the right product?

Explore all of our products under Doxepin hydrochloride

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKDB2419
MKCV8169
MKCQ8694
MKCQ5167
MKCM2122

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Doxepin effects on chronic pain, depression and plasma opioids.
Hameroff SR , et al.
The Journal of Clinical Psychiatry (1982)
Efficacy of doxepin in the treatment of chronic idiopathic urticaria
Goldsobel AB, et al.
The Journal of Allergy and Clinical Immunology, 78(5), 867-873 (1986)
Y Kitamura et al.
General pharmacology, 27(2), 285-291 (1996-03-01)
To clarify the presence of histamine receptor and its transmembrane mechanism in human T lymphocytes, we investigated the effects of agonists or antagonists of histamine receptor subtypes and bacterial toxins on intracellular concentration of Ca2+ [Ca2+]i), [3H]pyrilamine binding and c-fos
View All Related Papers

Global Trade Item Number

SKUGTIN
D4526-1G04061833565414
D4526-5G04061832090474

Questions

Reviews

No rating value

Active Filters