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D6946

(R)-DRF053 hydrochloride hydrate

≥98% (HPLC)

Synonym(s):

2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate

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25 mg

Available to ship TODAYfromMILWAUKEE

$484.00

About This Item

Empirical Formula (Hill Notation):
C23H27N7O · xHCl · yH2O
Molecular Weight:
417.51 (anhydrous free base basis)
NACRES:
NA.77
PubChem Substance ID:
329798839
UNSPSC Code:
12352200
MDL number:
MFCD17215921
Assay:
≥98% (HPLC)
Form:
powder

$484.00

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assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c3ccccn3)c4ncn(C(C)C)c4n1

InChI

1S/C23H27N7O.ClH.H2O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);1H;1H2/t17-;;/m1../s1

InChI key

ZOSNTFVWVJFXQO-ZEECNFPPSA-N

Biochem/physiol Actions

DRF053 is a more potent version of roscovitine.
DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
R2533SML0191P5234
(R)-DRF053 hydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

D6946

(R)-DRF053 hydrochloride hydrate

RS-127445 hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

R2533

RS-127445 hydrochloride

Valganciclovir hydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0191

Valganciclovir hydrochloride hydrate

Purvalanol B ≥97% (HPLC), solid

Sigma-Aldrich

P5234

Purvalanol B

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

form

powder

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: ≥30 mg/mL

solubility

DMSO: ≥20 mg/mL

solubility

H2O: ≥8 mg/mL

solubility

DMSO: soluble 37 mg/mL, H2O: insoluble

color

yellow

color

white to tan

color

white to tan

color

-

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
070M4725

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Articles

Cyclin-dependent Kinases (CDKs)

Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).

Mikołaj Słabicki et al.
Nature, 585(7824), 293-297 (2020-06-05)
Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid depletion of previously inaccessible targets2. They are clinically

Global Trade Item Number

SKUGTIN
D6946-25MG04061832270425
D6946-5MG04061832961583

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