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Anti-Daxx antibody produced in rabbit

Name: Anti-Daxx antibody produced in rabbit
Brand: SIGMA
Price: 610 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-BING2, Anti-DAP6, Anti-EAP1, Anti-SMIM40

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$610.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01865517

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

$610.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 120 kDa

species reactivity

mouse, human, monkey

technique(s)

microarray: suitable, western blot: 1:4,000 using human acute lymphoma Jurkat whole cell extract

UniProt accession no.

Q9UER7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DAXX(1616)
mouse ... Daxx(13163)

Description

General description

Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).

Immunogen

Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.

Application

Anti-Daxx antibody is suitable for:

western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
microarray
the detection and localization of Daxx by immunoblotting

Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.

Biochem/physiol Actions

Anti-Daxx specifically recognizes human Daxx (120 kDa).

The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB3500205	HPA008797	HPA008736
$Anti-Daxx antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich D7810 Anti-Daxx antibody produced in rabbit	$Anti-Daxx antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB3500205 Anti-Daxx antibody produced in rabbit	Sigma-Aldrich HPA008797 Anti-DAXX antibody produced in rabbit	Sigma-Aldrich HPA008736 Anti-DAXX antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate unconjugated
Gene Information human ... DAXX(1616) mouse ... Daxx(13163)	Gene Information human ... DAXX(1616)	Gene Information human ... DAXX(1616)	Gene Information human ... DAXX(1616)
UniProt accession no. Q9UER7	UniProt accession no. Q9UER7	UniProt accession no. -	UniProt accession no. Q9UER7

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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