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D8638

Dodecyltrimethylammonium bromide

≥98%

Synonym(s):

Lauryltrimethylammonium bromide

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25 g
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$228.00
100 g
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$628.00

About This Item

Linear Formula:
CH3(CH2)11N(CH3)3Br
CAS Number:
1119-94-4
Molecular Weight:
308.34
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24894108
EC Number:
214-290-3
Beilstein/REAXYS Number:
3597463
MDL number:
MFCD00011767

$228.00

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biological source

synthetic (oragnic)

Quality Level

200

description

cationic

assay

≥98%

form

powder

mol wt

308.34 g/mol

mp

246 °C (dec.) (lit.)

solubility

954 g/L at 20 °C

density

1.17 g/cm3 at 20 °C (68 °F)

application(s)

(Solubilizing proteins, cell lysis)

SMILES string

[Br-].CCCCCCCCCCCC[N+](C)(C)C

InChI

1S/C15H34N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16(2,3)4;/h5-15H2,1-4H3;1H/q+1;/p-1

InChI key

XJWSAJYUBXQQDR-UHFFFAOYSA-M

General description

Dodecyltrimethylammonium bromide (DTAB) is a versatile quaternary ammonium surfactant with a wide range of applications in cell biology and biochemical research. Its unique properties make it a valuable tool for solubilizing proteins and peptides, extracting DNA, and lysing cells. In proteomics research, DTAB plays a crucial role in protein solubilization and purification. Its ability to disrupt hydrophobic interactions and electrostatic forces allows it to effectively solubilize membrane-bound proteins and peptides, making them accessible for analysis and characterization. This property is particularly important in proteomics studies involving membrane proteins, which are often difficult to solubilize using conventional methods.

Beyond protein solubilization, this cationic detergent also finds application in DNA extraction procedures. Its ability to interact with DNA and alter its conformation facilitates the release of DNA from cellular components, enabling its subsequent purification and analysis. This property is particularly useful in the isolation of DNA from various biological samples, including tissues, cells, and microorganisms. Furthermore, DTAB demonstrates effectiveness in cell lysis processes. Its ability to disrupt cell membranes and release intracellular components makes it a valuable tool for breaking down cells and accessing their contents. This property has applications in various biological studies, including protein extraction, enzyme assays, and cellular component analysis.

Dodecyltrimethylammonium bromide (DTAB) stands as a versatile and widely applicable surfactant with a diverse range of applications in proteomics research, cell biology, and biochemical research. Its ability to solubilize proteins and peptides, extract DNA, and lyse cells makes it an essential tool for various biological studies and analytical techniques.

Application

Dodecyltrimethylammonium bromide has been used to lyse neonatal normal human epidermal keratinocyte (NHEK) cells for the quantification of intracellular nicotinamide adenine dinucleotide phosphate (NADP+) and NADPH (reduced form) content.
Dodecyltrimethylammonium bromide has been used in a study to assess the distribution of binary mixed counterions in surfactant adsorbed films. It has also been used in a study to investigate chain length compatibility of surfactants for extraction of organophosphorous pesticides. [1]

Features and Benefits

High-quality compound for your cell biology and biochemical research

Other Notes

For additional information on our range of Biochemicals, please complete this form.

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Dodecyltrimethylammonium bromide ≥98%

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

30725

Decyltrimethylammonium bromide

form

powder

form

crystals

form

liquid

form

powder

assay

≥98%

assay

~99%

assay

≥98.5% (AT)

assay

≥98.0% (NT)

application(s)

(Solubilizing proteins, cell lysis)

application(s)

-

application(s)

-

application(s)

-

mol wt

308.34 g/mol

mol wt

308.34 g/mol

mol wt

308.34 g/mol

mol wt

-

biological source

synthetic (oragnic)

biological source

-

biological source

-

biological source

-

solubility

954 g/L at 20 °C

solubility

H2O: 0.1 M at 20 °C, clear, colorless

solubility

-

solubility

-

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pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000541785
0000526940
0000526940
0000541785
0000508982

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Annabell Plauth et al.
Free radical biology & medicine, 99, 608-622 (2016-10-23)
Resveratrol has gained tremendous interest owing to multiple reported health-beneficial effects. However, the underlying key mechanism of action of this natural product remained largely controversial. Here, we demonstrate that under physiologically relevant conditions major biological effects of resveratrol can be
Study on the distribution of binary mixed counterions in surfactant adsorbed films by total reflection XAFS measurements
Y Imai et al.
Journal of Colloid and Interface Science, 15, 219-224 (2012)
Xiaofeng Chang et al.
Journal of colloid and interface science, 377(1), 291-298 (2012-04-28)
This study reported, for the first time systematically, photodegradation of Rhodamine B (RhB) in aqueous solution over BiOCl and BiOBr semiconductors. Under visible light irradiation (λ>400 nm, λ>420 nm and λ=550±15 nm), RhB adsorbed on the surface of BiOCl and
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Global Trade Item Number

SKUGTIN
D8638-25G04061835544219
D8638-100G04061835544202

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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