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1-Deoxymannojirimycin hydrochloride

Name: 1-Deoxymannojirimycin hydrochloride
Brand: SIGMA

Synonym(s):

1-Deoxymannojirimycin HCl, 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₃NO₄ · HCl

CAS Number:

73465-43-7

Molecular Weight:

199.63

NACRES:

NA.76

PubChem Substance ID:

24894265

UNSPSC Code:

51102829

MDL number:

MFCD00083611

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Properties

form

powder

Quality Segment

200

color

white to off-white

solubility

H₂O: 10 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1

InChI key

ZJIHMALTJRDNQI-MVNLRXSJSA-N

Description

General description

Chemical structure: glucosamine

Application

1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.

Biochem/physiol Actions

1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.

Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.

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This Item	D9305	P9620	S9007
Sigma-Aldrich D9160 1-Deoxymannojirimycin hydrochloride	Sigma-Aldrich D9305 1-Deoxynojirimycin hydrochloride	Sigma-Aldrich P9620 Puromycin dihydrochloride	Sigma-Aldrich S9007 Spectinomycin dihydrochloride pentahydrate
description -	description -	description Ready Made Solution, from Streptomyces alboniger, 10 mg/mL in H₂O, suitable for cell culture	description potency: ≥603 μg per mg
antibiotic activity spectrum viruses	antibiotic activity spectrum viruses	antibiotic activity spectrum neoplastics, Gram-positive bacteria, parasites	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria
mode of action enzyme \| inhibits	mode of action enzyme \| inhibits	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 200
form powder	form powder	form ready-to-use solution	form powder
solubility H₂O: 10 mg/mL	solubility water: 19.60-20.40 mg/mL, clear, colorless	solubility H₂O: soluble 10 mg/mL	solubility H₂O: soluble 50 mg/mL
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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