D9533 is soluble in H2O up to a concentration of 50mg/ml.
The solubility in DMSO is not assayed.
D9533
Deferoxamine mesylate salt
≥92.5% (TLC), powder, iron-chelating agent
Synonym(s):
DFX mesylate, DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 g | Check Cart for Availability | $156.00 |
About This Item
Empirical Formula (Hill Notation):
C25H48N6O8 · CH4O3S
CAS Number:
Molecular Weight:
656.79
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
205-314-3
MDL number:
Product Name
Deferoxamine mesylate salt, ≥92.5% (TLC), powder
Quality Level
assay
≥92.5% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key
IDDIJAWJANBQLJ-UHFFFAOYSA-N
Application
Biochem/physiol Actions
An iron chelator used often in the studies of cell proliferation and apoptosis. Also reported to induce p53.
An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form - | form solid |
| assay ≥92.5% (TLC) | assay ≥98% (HPLC) | assay - | assay - |
| Quality Level 200 | Quality Level 100 | Quality Level 300 | Quality Level - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
| solubility H2O: 50 mg/mL | solubility water: 50 mg/mL | solubility - | solubility - |
| color white to off-white | color faint yellow | color - | color - |
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Viable but nonculturable (VBNC) bacteria describes cells that cannot be normally cultured however, “resuscitation” of these cells can be mediated by a physical and different kind of chemical stimuli.
E Porreca et al.
Arteriosclerosis and thrombosis : a journal of vascular biology, 14(2), 299-304 (1994-02-01)
Vascular smooth muscle cell (VSMC) growth is a primary component of accelerated and spontaneous atherosclerosis. Previous studies have shown that iron may be involved in the control of enzymatic activities that modulate DNA synthesis in human cells. In this study
S Bereswill et al.
Journal of bacteriology, 182(21), 5948-5953 (2000-10-13)
Homologs of the ferric uptake regulator Fur and the iron storage protein ferritin play a central role in maintaining iron homeostasis in bacteria. The gastric pathogen Helicobacter pylori contains an iron-induced prokaryotic ferritin (Pfr) which has been shown to be
Biodegradable hypoxia biomimicry microspheres for bone tissue regeneration.
Lina Hadidi et al.
Journal of biomaterials applications, 34(7), 1028-1037 (2019-10-28)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D9533-1G | 04061835556632 |
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How do you reconstitute them in DMSO for drug assays?
1 answer-
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What are the recommended storage conditions for stock solutions of item D9533, Deferoxamine mesylate salt? Additionally, is this product sensitive to light?
1 answer-
Stock solutions of item D9533, Deferoxamine mesylate salt, should be aliquoted and stored at -20°C for up to 1 month. This product is not sensitive to light.
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