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E0881

Elastatinal

powder

Synonym(s):

(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$200.00
$170.00
10 mg

Available to ship TODAYfromMILWAUKEE

$364.00
25 mg

Available to ship TODAYfromMILWAUKEE

$743.00

About This Item

Empirical Formula (Hill Notation):
C21H36N8O7
CAS Number:
Molecular Weight:
512.56
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
EC Number:
257-426-7
Beilstein/REAXYS Number:
873543

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Product Name

Elastatinal, microbial

biological source

microbial

Quality Level

form

powder

solubility

water: 20 mg/mL, clear, faintly yellow to yellow

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1

InChI

1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

InChI key

IJWCGVPEDDQUDE-YGJAXBLXSA-N

Biochem/physiol Actions

Potent, irreversible elastase inhibitor.
Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

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This Item
SML3263SML2301E9658
biological source

microbial

biological source

-

biological source

-

biological source

-

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

100

form

powder

form

powder

form

powder

form

-

solubility

water: 20 mg/mL, clear, faintly yellow to yellow

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 14 mg/mL at 60 °C (warming for 5 minutes), DMSO: 64 mg/mL

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Product Information Sheet


Valentina Grano et al.
Biotechnology progress, 20(3), 968-974 (2004-06-05)
The inhibitory power of three different active Nylon membranes, separately loaded with three different protease inhibitors, was studied with the aim of reducing the increased elastase concentration occurring during hemodialysis or extracorporeal blood circulation in patients undergoing cardiopulmonary bypass. Chemical
M K Marschütz et al.
Biomaterials, 21(14), 1499-1507 (2000-06-29)
A drug-carrier matrix has been developed which protects embedded insulin from degradation by the luminally secreted serine-proteases trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1) and elastase (EC 3.4.21.36) in vitro. Increasing amounts of the Bowman-Birk inhibitor (BBI) and elastatinal, respectively, were
R L Stein et al.
Experientia, 41(5), 638-640 (1985-05-15)
Human leukocyte elastase can be proteolytically inactivated by bovine pancreatic trypsin. Neither porcine pancreatic elastase nor bovine pancreatic chymotrypsin causes inactivation of leukocyte elastase, nor are trypsin, pancreatic elastase, or chymotrypsin themselves susceptible to proteolysis. The trypsin-catalyzed inactivation of leukocyte



Global Trade Item Number

SKUGTIN
E0881-25MG04061833270660
E0881-10MG04061833270653
E0881-5MG04061833270677

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