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E114

EHNA hydrochloride

≥98% (HPLC), powder, adenosine deaminase inhibitor

Synonym(s):

erythro-9-(2-Hydroxy-3-nonyl)­adenine hydrochloride, erythro-9-Amino-β-hexyl-­α-methyl-9H-purine-9-ethanol hydrochloride

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25 mg

Available to ship TODAYfromMILWAUKEE

$310.00
100 mg

Available to ship TODAYfromMILWAUKEE

$1,050.00

About This Item

Empirical Formula (Hill Notation):
C14H23N5O · HCl
CAS Number:
58337-38-5
Molecular Weight:
313.83
UNSPSC Code:
12352200
PubChem Substance ID:
24277713
NACRES:
NA.77
MDL number:
MFCD00151066
Assay:
≥98% (HPLC)
Quality level:
100
Storage condition:
desiccated

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Product Name

EHNA hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

storage condition

desiccated

solubility

DMSO: >10 mg/mL, H2O: >10 mg/mL

SMILES string

Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12

InChI

1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1

InChI key

VVDXNJRUNJMYOZ-VZXYPILPSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

General description

EHNA is an adenosine deaminase inhibitor. It possesses antitumor action.

Application

EHNA hydrochloride has been used to treat microexplant culture to examine the direction and the motor responsible for the movement of autophagosomes in axons. It has also been used in nucleoside supplementation to inhibit the breakdown of deoxyadenosine by the enzyme adenosine deaminase.

Biochem/physiol Actions

Adenosine deaminase inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
324630H9414G3796
EHNA hydrochloride ≥98% (HPLC)

Sigma-Aldrich

E114

EHNA hydrochloride

EHNA, Hydrochloride The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and adenosine deaminase.

Sigma-Aldrich

324630

EHNA, Hydrochloride

Halofantrine hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

H9414

Halofantrine hydrochloride

Granisetron hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

G3796

Granisetron hydrochloride

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

DMSO: >10 mg/mL, H2O: >10 mg/mL

solubility

water: 25 mg/mL

solubility

DMSO: >10 mg/mL

solubility

H2O: >10 mg/mL

storage condition

desiccated

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

desiccated

storage condition

desiccated

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

Gene Information

-

Gene Information

-

Gene Information

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000554312
0000554313
0000403984
0000554312
0000554313

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Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Dynein-and activity-dependent retrograde transport of autophagosomes in neuronal axons
Katsumata K, et al.
Autophagy, 6(3), 378-385 (2010)
Sarah M Bowers et al.
Pediatric rheumatology online journal, 18(1), 54-54 (2020-07-12)
Human adenosine deaminase 2 (ADA2) is an extracellular enzyme that negatively regulates adenosine-mediated cell signaling by converting adenosine to inosine. Altered ADA2 enzyme activity has been associated with some viral infections and rheumatic diseases. The potential utility of ADA2 as
Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines.
H J Schaeffer et al.
Journal of medicinal chemistry, 17(1), 6-8 (1974-01-01)
View All Related Papers

Global Trade Item Number

SKUGTIN
E114-25MG04061833601402
E114-100MG04061832947488

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