E166

Monoclonal Anti-Endothelin-1 antibody produced in mouse

Name: Monoclonal Anti-Endothelin-1 antibody produced in mouse
Brand: SIGMA
Price: 718 USD

clone TR.ET.48.5, purified antibody

Slide 1 of 1

Select a Size

100 μL

$718.00

Check Cart for Availability

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00162279

Key Documents

View All Documentation

Product Name

Monoclonal Anti-Endothelin-1 antibody produced in mouse, clone TR.ET.48.5, purified antibody

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

TR.ET.48.5, monoclonal

species reactivity

rat, human, sheep

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250
radioimmunoassay: 1:25,000
western blot: suitable

isotype

IgG1

UniProt accession no.

P05305

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	M8159	I2018	SAB1403792
Sigma-Aldrich E166 Monoclonal Anti-Endothelin-1 antibody produced in mouse	Sigma-Aldrich M8159 Monoclonal Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody produced in mouse	Sigma-Aldrich I2018 Monoclonal Anti-Insulin antibody produced in mouse	Sigma-Aldrich SAB1403792 Monoclonal Anti-ERN1 antibody produced in mouse
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... EDN1(1906)	Gene Information human ... MAPK1(5594), MAPK3(5595) mouse ... Mapk1(26413), Mapk3(26417) rat ... Mapk1(116590), Mapk3(50689)	Gene Information human ... INS(3630)	Gene Information human ... ERN1(2081)
species reactivity rat, human, sheep	species reactivity human, Caenorhabditis elegans, Xenopus, Drosophila, hamster, rat, bovine, mouse, yeast	species reactivity feline, human, rat, horse, rabbit, guinea pig, bovine, monkey, sheep, canine, pig	species reactivity human
clone TR.ET.48.5, monoclonal	clone MAPK-YT, monoclonal	clone K36AC10, monoclonal	clone 3D1, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified antibody	antibody form ascites fluid	antibody form ascites fluid	antibody form purified immunoglobulin

Application

Monoclonal Anti-Endothelin-1 antibody produced in mouse is suitable for immunoblotting and immunocytochemistry.It is also suitable for radioimmunoassay (RIA) at a working dilution of 1:25,000 and for immunohistochemistry at 1:250 working dilution using formalin-fixed, paraffin-embedded tissue sections.

Biochem/physiol Actions

ET-1, a 21 amino acid peptide, is produced by vascular endothelial cells. It is a potent vasoconstrictor and plays an important role in the homeostasis of the circulatory system. It is also important in pathogenesis of cardiovascular diseases. It is also involved in contraction of airway and intestinal smooth muscle. It releases vasodilator prostaglandins and nitric oxide (NO). It also plays a role in mitogenic effects on vascular smooth muscle cells and fibroblasts, stimulation of atrial natriuretic peptide secretion from atrial cardiocytes and inhibition of renin release. ET-1 is expressed in the spinal cord and dorsal root ganglia, where it may serve as a neurotransmitter/neuromodulator.

The antibody shows little cross-reactivity to related peptides and no known cross-reactivity to non-related peptides.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Endothelin consists of a family of potent vasoconstrictor peptides, which include four structurally related isoforms, ET-1, ET-2, ET-3 and vasointestinal contractor (VIC, β -ET)

Immunogen

endothelin-1 (ET-1) conjugated to KLH

Physical form

Solution in phosphate buffered saline, containing 0.05% sodium azide

Not finding the right product?

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation.

Aykut Gram et al.

The Journal of reproduction and development, 63(3), 235-245 (2017-02-22)

Utero-placental (Ut-Pl) angiogenesis and blood flow are fundamental for successful outcome of pregnancy. They are controlled by numerous vasodilator and vasoconstrictor systems such as endothelins (EDNs) and the renin angiotensin system. Dogs possess an invasive type of placentation, classified as

Endothelin inhibits renin release from isolated rat glomeruli.

H Rakugi et al.

Biochemical and biophysical research communications, 155(3), 1244-1247 (1988-09-30)

The effect of endothelin on renin release from isolated rat glomeruli was examined. Endothelin inhibited basal renin release in a dose-dependent manner with an IC50 of 1.0 x 10(-9) M. Endothelin also inhibited renin release stimulated by isoproterenol (10(-5) M).

Obesity, type 2 diabetes, and impaired insulin-stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1.

Leryn J Reynolds et al.

Journal of applied physiology (Bethesda, Md. : 1985), 122(1), 38-47 (2016-11-01)

Increased endothelin-1 (ET-1) and reduced endothelial nitric oxide phosphorylation (peNOS) are hypothesized to reduce insulin-stimulated blood flow in type 2 diabetes (T2D), but studies examining these links in humans are limited. We sought to assess basal and insulin-stimulated endothelial signaling

Expression and functional implications of luteal endothelins in pregnant and non-pregnant dogs.

Aykut Gram et al.

Reproduction (Cambridge, England), 150(5), 405-415 (2015-08-05)

Luteal development is regulated by many locally produced mediators, e.g., prostaglandins and angiogenic factors. However, the role and function of vasoactive factors in the canine corpus luteum (CL) remain largely unknown. Consequently, expression of the endothelin (ET) receptors-A and -B

Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

M W MacCumber et al.

Proceedings of the National Academy of Sciences of the United States of America, 87(6), 2359-2363 (1990-03-01)

We have explored the cellular loci of endothelin (ET) actions and formation in the brain, using cerebellar mutant mice as well as primary and continuous cell cultures. A glial role is favored by several observations: (i) mutant mice lacking neuronal

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service