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E166

Monoclonal Anti-Endothelin-1 antibody produced in mouse

Name: Monoclonal Anti-Endothelin-1 antibody produced in mouse
Brand: SIGMA
Price: 641 EUR

clone TR.ET.48.5, purified antibody

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Ihnen/SKU	Verfügbarkeit	Preis
100 μL	Warenkorb auf Verfügbarkeit prüfen	€ 641,00

Über diesen Artikel

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00162279

Conjugate:

unconjugated

Clone:

TR.ET.48.5, monoclonal

Application:

ICC, IHC (p), RIA, WB

Citations:

€ 641,00

Warenkorb auf Verfügbarkeit prüfen

Technischer Dienst

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Eigenschaften

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

TR.ET.48.5, monoclonal

species reactivity

rat, human, sheep

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250, radioimmunoassay: 1:25,000, western blot: suitable

isotype

IgG1

UniProt accession no.

P05305

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EDN1(1906)

Beschreibung

General description

Endothelin consists of a family of potent vasoconstrictor peptides, which include four structurally related isoforms, ET-1, ET-2, ET-3 and vasointestinal contractor (VIC, β -ET)

Immunogen

endothelin-1 (ET-1) conjugated to KLH

Application

Monoclonal Anti-Endothelin-1 antibody produced in mouse is suitable for immunoblotting and immunocytochemistry.It is also suitable for radioimmunoassay (RIA) at a working dilution of 1:25,000 and for immunohistochemistry at 1:250 working dilution using formalin-fixed, paraffin-embedded tissue sections.

Biochem/physiol Actions

ET-1, a 21 amino acid peptide, is produced by vascular endothelial cells. It is a potent vasoconstrictor and plays an important role in the homeostasis of the circulatory system. It is also important in pathogenesis of cardiovascular diseases. It is also involved in contraction of airway and intestinal smooth muscle. It releases vasodilator prostaglandins and nitric oxide (NO). It also plays a role in mitogenic effects on vascular smooth muscle cells and fibroblasts, stimulation of atrial natriuretic peptide secretion from atrial cardiocytes and inhibition of renin release. ET-1 is expressed in the spinal cord and dorsal root ganglia, where it may serve as a neurotransmitter/neuromodulator.

The antibody shows little cross-reactivity to related peptides and no known cross-reactivity to non-related peptides.

Physical form

Solution in phosphate buffered saline, containing 0.05% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Dieser Artikel	WH0001906M1	M8159	WH0001907M1
Sigma-Aldrich E166 Monoclonal Anti-Endothelin-1 antibody produced in mouse	Sigma-Aldrich WH0001906M1 Monoclonal Anti-EDN1 antibody produced in mouse	Sigma-Aldrich M8159 Monoklonale Anti-MAP-Kinase, aktiviert (Diphosphorylierter ERK-1&2) in Maus hergestellte Antikörper	Sigma-Aldrich WH0001907M1 Monoclonal Anti-EDN2 antibody produced in mouse
species reactivity rat, human, sheep	species reactivity human	species reactivity human, Caenorhabditis elegans, Xenopus, Drosophila, hamster, rat, bovine, mouse, yeast	species reactivity human
clone TR.ET.48.5, monoclonal	clone 3D6, monoclonal	clone MAPK-YT, monoclonal	clone 3B4-1C5, monoclonal
Gene Information human ... EDN1(1906)	Gene Information human ... EDN1(1906)	Gene Information human ... MAPK1(5594), MAPK3(5595) mouse ... Mapk1(26413), Mapk3(26417) rat ... Mapk1(116590), Mapk3(50689)	Gene Information human ... EDN2(1907)
antibody form purified antibody	antibody form purified immunoglobulin	antibody form ascites fluid	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source mouse

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Lagerklasse

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c