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E2656

(−)-Epothilone B

from Sorangium cellulosum, ≥98% (HPLC)

Synonym(s):

EPO906, EpoB, Patupilone

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Size/SKUAvailabilityPrice
1 mg
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$59.10
5 mg
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$184.00

About This Item

Empirical Formula (Hill Notation):
C27H41NO6S
CAS Number:
Molecular Weight:
507.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
lyophilized powder
Storage condition:
desiccated, protect from light

$59.10


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biological source

Sorangium cellulosum

Quality Segment

assay

≥98% (HPLC)

form

lyophilized powder

storage condition

desiccated, protect from light

color

white to off-white

storage temp.

−20°C

SMILES string

[H][C@]1(C[C@]2([H])O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)\C(C)=C\c3csc(C)n3

InChI

1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

InChI key

QXRSDHAAWVKZLJ-PVYNADRNSA-N

General description

Epothilones has antimitotic properties. It prevents microtubule depolymerization and competitively blocks paclitaxel binding to microtubules. Epothilone B is used to treat metastatic breast cancer (MBC).

Biochem/physiol Actions

(-)-Epothilone B is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoB has similar biological properties to EpoA. However, EpoB is 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells). (-)-Epothilone B is similar to paclitaxel in binding displacement, and a substitution for paclitaxel in dependent cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).
EpoB is a microtubule stabilizing drug and natural macrolide antitumor.

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This Item
N3876L9756PHL89517
description

from Sorangium cellulosum, ≥98% (HPLC)

description

≥99% (GC), liquid

description

≥99% (GC)

description

phyproof® Reference Substance

assay

≥98% (HPLC)

assay

≥99% (GC)

assay

≥99% (GC)

assay

≥95.0% (GC)

form

lyophilized powder

form

liquid

form

powder

form

crystals

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

-

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

storage condition

desiccated, protect from light

storage condition

-

storage condition

-

storage condition

-

color

white to off-white

color

yellow

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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