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E2764

Anti-Endothelin Receptor B antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-ET-B, Anti-ET-Specific Endothelin Receptor

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0.05 mL

Available to ship TODAYfromMILWAUKEE

$344.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02677992
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB CL
Citations:
11

$344.00

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100, western blot (chemiluminescent): 1:200

UniProt accession no.

P21451

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Ednrb(50672)

General description

Endothelin Receptor B (EDNRB) is a G-protein coupled receptor and that consists of seven transmembrane domains. EDNRB gene is located on the human chromosome at 13q22.3.

Immunogen

synthetic peptide corresponding to amino acids 298-313 of rat endothelin receptor type B. The epitope is identical in all known vertebrate ET-B receptors

Application

Anti-Endothelin Receptor B antibody produced in rabbit has been used in immunohistochemistry (1:100).

Biochem/physiol Actions

EDNRB Endothelin receptor type B (ETB) plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.
Mutations in the EDNRB gene are associated with Hirschsprung disease.

Physical form

Lyophilized at 0.8 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item
E9905E9780S8305
Anti-Endothelin Receptor B antibody produced in rabbit affinity isolated antibody, lyophilized powder

Sigma-Aldrich

E2764

Anti-Endothelin Receptor B antibody produced in rabbit

Anti-Endothelin B Receptor antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

E9905

Anti-Endothelin B Receptor antibody produced in rabbit

Anti-Endothelin A Receptor antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

E9780

Anti-Endothelin A Receptor antibody produced in rabbit

Anti-Substance P Receptor antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

Sigma-Aldrich

S8305

Anti-Substance P Receptor antibody produced in rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100, western blot (chemiluminescent): 1:200

technique(s)

immunocytochemistry: 4-11 μg/mL using human adrenal tissue, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-11 μg/mL using human adrenal tissue

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3-16 μg/mL using human heart tissue

technique(s)

immunohistochemistry (frozen sections): 1:5,000 using 4% paraformaldehyde (with picric acid/glutaraldehyde)-fixed, frozen, rat brain sections., microarray: suitable, western blot (chemiluminescent): 1:2,000 using a rat brain membrane fraction extract

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW7968
MKCT7690
MKCR8225
MKBS8557V
051M1573V

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Related Content

Data Sheet - E2764

Instructions

Victor M Salinas-Torres et al.
Pediatric surgery international, 34(9), 931-943 (2018-08-11)
Gastroschisis has been assumed to have a low rate of syndromic and primary malformations. We aimed to systematically review and explore the frequency and type of malformations/chromosomal syndromes and to identify significant biological/genetic roles in gastroschisis. Population-based, gastroschisis-associated anomalies/chromosomal defects
J Amiel et al.
Human molecular genetics, 5(3), 355-357 (1996-03-01)
Hirschsprung disease (HSCR, aganglionic megacolon) is a frequent congenital malformation regarded as a multigenic neurocristopathy. Two susceptibility genes have been recently identified in HSCR, namely the RET proto-oncogene and the endothelin B receptor (EDNRB) gene. Hitherto however, homozygosity for EDNRB
Chun-Yun Wu et al.
Glia, 54(6), 513-525 (2006-08-10)
Amoeboid microglial cells (AMC) which transiently exist in the corpus callosum in the postnatal rat brain expressed endothelins (ETs), specifically endothelin-1 (ET-1) and ET3 as revealed by real time RT-PCR. ET immunoreactive AMC occurred in large numbers at birth, but
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Global Trade Item Number

SKUGTIN
E2764-.2ML04061837832215
E2764-.05ML04061837832208

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