The synthetic peptide corresponds to amino acid residues 413-426 of rat ET-A (Accession P26684) and has multiple isoforms. There are multiple glycosylation and phosphorylation sites (Accession P26684). After performing a western blot, you will observe multiple bands, with sizes approximately around 48 KDa, 28 KDa, and so on. For further details on the protein size and its different isoforms, please visit the UniProt website and refer to the following link: UniProt - Accession P26684.
E3651
Anti-Endothelin Receptor A antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-ET-A, Anti-ET1-Specific Endothelin Receptor
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Size/SKU | Availability | Price |
|---|---|---|
0.05 mL | Check Cart for Availability | $332.00 |
0.2 mL | Check Cart for Availability | $992.00 $843.20 |
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
8
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, pig, chicken, bovine
technique(s)
immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections, western blot: 1:200 using rat brain membranes and ECL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EDNRA(1909)
rat ... Ednra(24326)
Immunogen
synthetic peptide corresponding to amino acids 413-426 of rat ET-A (with additional N-terminal cysteine).
Application
Anti-Endothelin Receptor A antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 using rat brain sections or rat lung paraffin embedded sections and western blotting at a dilution of 1:200 using rat brain membranes and ECL.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETAR mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.
The epitope is highly conserved in human, swine, bovine and chicken ET-A.
Physical form
Lyophilized from a solution of phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| description affinity isolated antibody, lyophilized powder | description affinity isolated antibody, buffered aqueous solution | description affinity isolated antibody, buffered aqueous solution | description affinity isolated antibody, lyophilized powder |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| Gene Information human ... EDNRA(1909) | Gene Information human ... EDNRB(1910) | Gene Information human ... EDNRA(1909) | Gene Information human ... GABRG2(2566) |
| technique(s) immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections, western blot: 1:200 using rat brain membranes and ECL | technique(s) immunocytochemistry: 4-11 μg/mL using human adrenal tissue, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-11 μg/mL using human adrenal tissue | technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3-16 μg/mL using human heart tissue | technique(s) western blot: 1:200 using rat brain membrane |
Still not finding the right product?
Try our Product Selector Tool to narrow your options
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
-
Could you provide the molecular weight (MW) of the antibody E3651 Anti-Endothelin Receptor A?
1 answer-
Helpful?
-