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E3789

Amphotericin B – Low Endotoxin

Less than 5 EU/mg, suitable for cell culture

Synonym(s):

Amphotericin B – Low Endotoxin

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100 mg
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$149.00
500 mg
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$625.00
$531.25
1 g
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$1,040.00

About This Item

NACRES:
NA.76
UNSPSC Code:
12352207

$149.00

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biological source

Streptomyces sp. (Microbial)

form

powder

mol wt

924.08

technique(s)

cell culture | mammalian: suitable

storage temp.

2-8°C

General description

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. It has a high affinity for sterols,primarily ergosterols, of fungal and bacterial cell membranes.After binding to sterols, it forms channels in the membranes, causing small molecules to leak out.Amphotericin B is effective against fungi and yeast.The name of the drug is derived from the amphoteric behavior of the drug, due to the carboxyl group on the main ring and a primary amino group on the mycosamine ring.
Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.At sub-lethal concentrations, this drug stimulates either the activity of some membrane enzymes or cellular metabolism,in particular stimulation of some cells of the immune system.

Preparation Note

Amphotericin B remains active for 3 days in culture at 37°C. For long term, storage at 2−8°C, protected from air and light, is recommended. Under these conditions the products remain active for 5 years.
If reconstituted at 25 mg/10 mL of sterile water, there is no need to filter sterilize. This will yield a slightly hazy yellow solution.

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This Item
A2942A2411A4888
Amphotericin B – Low Endotoxin Less than 5 EU/mg, suitable for cell culture

Sigma-Aldrich

E3789

Amphotericin B – Low Endotoxin

Amphotericin B solution 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture

Sigma-Aldrich

A2942

Amphotericin B solution

Amphotericin B from Streptomyces sp. BioReagent, suitable for cell culture, ~80% (HPLC)

Sigma-Aldrich

A2411

Amphotericin B from Streptomyces sp.

Amphotericin B from Streptomyces sp. ~80% (HPLC), powder

Sigma-Aldrich

A4888

Amphotericin B from Streptomyces sp.

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

form

powder

form

liquid

form

solid

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

biological source

Streptomyces sp. (Microbial)

biological source

-

biological source

Streptomyces sp.

biological source

Streptomyces sp.

mol wt

924.08

mol wt

-

mol wt

-

mol wt

-

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H372

Hazard Classifications

STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000440219
0000440219
0000363191
0000315690
0000363191

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Data Sheet - E3789

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