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E4643

Heparin-Binding EGF-Like Growth Factor human

Name: Heparin-Binding EGF-Like Growth Factor human
Brand: SIGMA
Price: 426 EUR
Availability: InStock

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

Synonym(e):

hHB-EGF, HB-EGF, Heparin-Binding Epidermal Growth Factor-Like Growth Factor

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Packungsgröße	SKU	Verfügbarkeit	Preis
50 μg		Ab HEUTE lieferbarvonSchnelldorf	426,00 €
250 μg		Warenkorb auf Verfügbarkeit prüfen	665,00 €

Über diesen Artikel

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00212935

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf21 cells

Assay:

≥97% (SDS-PAGE and N-terminal analysis)

Form:

lyophilized powder

Mol wt:

9.5 kDa

426,00 €

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Eigenschaften

Produktname

Heparin-Binding EGF-Like Growth Factor human, HB-EGF, recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

100

recombinant

expressed in baculovirus infected Sf21 cells

assay

≥97% (SDS-PAGE and N-terminal analysis)

form

lyophilized powder

potency

≤3 ng/mL

quality

endotoxin tested

mol wt

9.5 kDa

packaging

pkg of 50 and 250 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

Q99075

storage temp.

−20°C

Beschreibung

Biochem/physiol Actions

Heparin-binding epidermal growth factor (HB-EGF), like BTC, is a heparin-binding EGF family member. Natural soluble HB-EGF is a 19 kDa glycoprotein of multiple forms due to heterogeneous truncations. Soluble HB-EGF is mitogenic and chemotactic for fibroblasts, keratinocytes, and smooth muscle cells but not capillary endothelial cells. Production of HB-EGF is detected in monocytes, macrophages, and vascular and aortic smooth muscle cells (SMC). HB-EGF may play a role in the pathogenesis of atherosclerosis. It may also be an effector of Jun-induced oncogenic transformation. HB-EGF binds to EGFR with high affinity and to ErbB with moderate affinity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to stimulate ³H-thymidine incorporation in the EGF-responsive BALB/3T3 cells.

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Dieser Artikel	H1404	E9644	P5208
Sigma-Aldrich E4643 Heparin-Binding EGF-Like Growth Factor human	Sigma-Aldrich H1404 Hepatocyte Growth Factor human	Sigma-Aldrich E9644 hEGF	Sigma-Aldrich P5208 Platelet-Derived Endothelial Cell Growth Factor human
biological source human	biological source human	biological source human	biological source human
assay ≥97% (SDS-PAGE and N-terminal analysis)	assay >95% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)
recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in Baculovirus infected High-5 cells	recombinant expressed in E. coli	recombinant expressed in baculovirus infected Sf21 cells
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
Quality Level 100	Quality Level 200	Quality Level 300	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
E4643-50UG	04061833603949
E4643-250UG	04061833603932

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