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E6657

Eplerenone

≥98% (HPLC), aldosterone blocker, powder

Sinónimos:

9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-, SC-66110

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A ustedes/SKUDisponibilidadPrecio
10 mg
Comprobar disponibilidad del carrito
MXP 6,233.00
50 mg
Comprobar disponibilidad del carrito
MXP 18,607.00
MXP 15,815.95

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Fórmula empírica (notación de Hill):
C24H30O6
Número CAS:
107724-20-9
Peso molecular:
414.49
MDL number:
MFCD05662207
UNSPSC Code:
51111800
PubChem Substance ID:
329798999
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

MXP 6,233.00

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Nombre del producto

Eplerenone, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed), H2O: insoluble

storage temp.

2-8°C

SMILES string

O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C

InChI

1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key

JUKPWJGBANNWMW-VWBFHTRKSA-N

Gene Information

human ... NR3C2(4306)

General description

Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction. Eplerenone is used for treating hypertension and central serous retinopathy. It exhibits potassium sparing diuretic effect.

Application

Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.

Biochem/physiol Actions

Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.
Eplerenone is an aldosterone antagonist.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Este artículo
Y00017041237553Y0001706
Eplerenone ≥98% (HPLC)

Sigma-Aldrich

E6657

Eplerenone

Eplerenone European Pharmacopoeia (EP) Reference Standard, European Pharmacopoeia (EP) Reference Standard

Y0001704

Eplerenone

Eplerenone United States Pharmacopeia (USP) Reference Standard

USP

1237553

Eplerenone

Eplerenone for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001706

Eplerenone for peak identification

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear (warmed), H2O: insoluble

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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